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Small baseline volume of left hippocampus is associated with subsequent conversion of MCI into dementia. The Göteborg MCI study.

Artikel i vetenskaplig tidskrift
Författare Carl Eckerström
Erik Olsson
Magnus Borga
Sven Ekholm
Susanne Ribbelin
Sindre Rolstad
Göran Starck
Åke Edman
Anders Wallin
Helge Malmgren
Publicerad i Journal of the Neurological Sciences
Volym 272
Nummer/häfte 1-2
Sidor 48-59
ISSN 0022-510X
Publiceringsår 2008
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för radiofysik
Institutionen för neurovetenskap och fysiologi
Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Institutionen för biomedicin
Filosofiska institutionen
Sidor 48-59
Språk en
Länkar dx.doi.org/10.1016/j.jns.2008.04.02...
Ämnesord Dementia, Alzheimer's disease, Vascular dementia, Mild cognitive impairment (MCI), Volumetric MRI, Hippocampus, Brain asymmetries
Ämneskategorier Diagnostisk radiologi, Psykiatri

Sammanfattning

Background: Earlier studies have reported that hippocampal atrophy can to some extent predict which patients with mild cognitive impairment (MCI) will subsequently convert to dementia, and that converters have an enhanced rate of hippocampal volume loss. Objective: To further validate the hypothesis that hippocampal atrophy predicts conversion from MCI to dementia, to relate baseline hippocampal volume to different forms of dementia, and to investigate the role of hippocampal side differences and rate of volume loss over time. Patients: The subjects (N = 68) include patients with MCI at baseline and progression to dementia at the two-year follow-up (N = 21), stable MCI patients (N = 21), and controls (N = 26). Among the progressing patients, 13 were diagnosed as having AD. Methods: The Göteborg MCI study is a clinically based longitudinal study with biannual clinical assessments. Hippocampal volumetry was performed manually on the MRI investigations at baseline and at the two-year follow-up. Results: Hippocampal volumetry could predict conversion to dementia in both the AD and the non-AD subgroup of converters. Left hippocampal volume in particular discriminated between converting and stable MCI. Cut off points for individual discrimination were shown to be potentially useful. The converting MCI group had a significantly higher rate of hippocampal volume loss as compared to the stable MCI group. Conclusions: In MCI patients, hippocampal volumetry at baseline gives prognostic information about possible development of AD and non-AD dementia. Contrary to earlier studies, we found that left hippocampal volume has the best predictive power. Reliable predictions appear to be possible in many individual cases.

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