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Plasminogen activator inhibitor 1 expression in platelets is not influenced by the 4G/5G promoter polymorphism

Artikel i vetenskaplig tidskrift
Författare Helén Brogren
Karin Wallmark
Sverker Jern
Lena Karlsson
Publicerad i Thrombosis Research
Volym 121
Nummer/häfte 6
Sidor 793-7
ISSN 0049-3848
Publiceringsår 2008
Publicerad vid Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin
Sidor 793-7
Språk en
Länkar dx.doi.org/10.1016/j.thromres.2007....
Ämnesord Fibrinolysis, Plasminogen activator inhibitor 1, Platelets, mRNA, Polymorphism
Ämneskategorier Kardiologi

Sammanfattning

In the present study we investigated the influence of the 4G/5G promoter polymorphism of the PAI-1 gene on the levels of PAI-1 mRNA and protein in platelets. After a screening of healthy male subjects, thirty-eight subjects homozygote for either the 4G or 5G allele were investigated. mRNA levels were quantified by real-time PCR and PAI-1 antigen in platelets and plasma was analysed by ELISA. The platelet PAI-1 mRNA levels correlated significantly with the PAI-1 antigen content, but there was no association between the polymorphism and mRNA levels, or protein levels in platelets. Also, plasma levels of PAI-1 antigen were not associated with homozygosity of the 4G/5G polymorphism, but as expected BMI and triglycerides emerged as significant predictors of plasma PAI-1 levels. The importance of the 4G/5G polymorphism on PAI-1 levels is controversial and the present study shows that although levels of platelet mRNA are related to its content of PAI-1 protein, there is no association between the 4G/5G promoter polymorphism and platelet PAI-1 mRNA or protein expression.

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