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Supportive periodontal therapy using mechanical instrumentation or 2% minocycline gel: a 12 month randomized, controlled, single masked pilot study.

Artikel i vetenskaplig tidskrift
Författare E McColl
K Patel
Gunnar Dahlén
M Tonetti
F Graziani
J Suvan
L Laurell
Publicerad i Journal of clinical periodontology
Volym 33
Nummer/häfte 2
Sidor 141-50
ISSN 0303-6979
Publiceringsår 2006
Publicerad vid Institutionen för odontologi
Sidor 141-50
Språk en
Länkar dx.doi.org/10.1111/j.1600-051X.2005...
Ämnesord Actinobacillus actinomycetemcomitans, drug effects, Adult, Anti-Bacterial Agents, administration & dosage, therapeutic use, Bacteroides, drug effects, Colony Count, Microbial, Dental Scaling, Female, Follow-Up Studies, Gels, Gingival Hemorrhage, drug therapy, microbiology, prevention & control, Humans, Male, Middle Aged, Minocycline, administration & dosage, therapeutic use, Periodontal Pocket, drug therapy, microbiology, prevention & control, Periodontitis, drug therapy, microbiology, prevention & control, Pilot Projects, Porphyromonas gingivalis, drug effects, Prevotella intermedia, drug effects, Prevotella nigrescens, drug effects, Root Planing, Single-Blind Method, Treponema denticola, drug effects
Ämneskategorier Oral mikrobiologi, Parodontologi

Sammanfattning

OBJECTIVE: To compare the short-term performance of subgingival local delivery of 2% minocycline gel and conventional subgingival debridement in supportive periodontal therapy (SPT) patients. METHODS: Forty adult patients having completed active treatment for moderate to advanced chronic periodontitis were included in a randomized, controlled, single masked maintenance care pilot study. Sites with residual pocket probing depths > or =5 mm and bleeding on probing were treated with either minocycline gel (minocycline-group) or scaling and root planing only (debridement-group) at baseline, 3, 6, and 9 months. Clinical and microbiological examinations were performed at baseline, 3, 6, 9, and 12 months. RESULTS: Full-mouth plaque and bleeding scores remained <10% and <20%, respectively, for both groups throughout the study. In both groups there was a persistent reduction in number of teeth and sites with probing pocket depths > or =5 mm (p<0.05) with no significant differences between the groups. The prevalence of Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Actinobacillus actinomycetemcomitans, Prevotella intermedia, and Prevotella nigrescens, remained at levels < or =10(5) in the majority of patients and sites in both groups. CONCLUSION: This pilot study failed to show a difference between local delivery of 2% minocycline gel as mono-therapy and traditional subgingival debridement in patients on SPT.

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