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Locally delivered doxycycline as an adjunct to mechanical debridement at retreatment of periodontal pockets.

Artikel i vetenskaplig tidskrift
Författare Cristiano Tomasi
Theofilos Koutouzis
Jan Wennström
Publicerad i Journal of periodontology
Volym 79
Nummer/häfte 3
Sidor 431-9
ISSN 0022-3492
Publiceringsår 2008
Publicerad vid Institutionen för odontologi
Sidor 431-9
Språk en
Länkar dx.doi.org/10.1902/jop.2008.070383
Ämneskategorier Parodontologi

Sammanfattning

Background: The aim of this study was to evaluate if adjunctive, locally delivered controlled-release doxycycline might improve the outcome of reinstrumentation of pathologic pockets persisting after initial periodontal therapy. Methods: Subjects with chronic periodontitis underwent initial treatment including full-mouth ultrasonic debridement and oral hygiene instructions. At the 3-month reexamination, 32 subjects with remaining pathologic sites were assigned randomly to one of two retreatment protocols: ultrasonic instrumentation alone (control) or ultrasonic instrumentation plus application of an 8.8% doxycycline gel (test). Clinical examinations of plaque, probing depth (PD), relative attachment level (RAL), and bleeding on probing were performed before retreatment (baseline) and after 3 and 9 months. Primary efficacy variables were the percentage of closed pockets, i.e., PD 0.05). At 9 months, both treatment groups showed a mean PD reduction of 1.1 mm. The mean RAL gain was 0.6 mm at 3 months and approximately 0.8 at 9 months for both groups. The probability of pocket closure was not improved by the adjunctive antibiotic therapy. Only factors at the tooth site level (plaque presence, furcation involvement, and presence of an intrabony defect) were identified by multilevel analysis as significant for the treatment outcome. Conclusion: Locally delivered doxycycline failed to improve the healing outcome of reinstrumentation of periodontal pockets showing a poor initial response to pocket/root debridement.

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