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A comparison of North American versus non-North American ADHD study populations.

Artikel i vetenskaplig tidskrift
Författare Jan K Buitelaar
Joanne Barton
Marina Danckaerts
Edgar Friedrichs
Christopher Gillberg
Philip L Hazell
Hans Hellemans
Mats Johnson
Luuk J Kalverdijk
Gabriele Masi
David Michelson
Olivier Revol
Javier San Sebastian
Shuyu Zhang
Alessandro Zuddas
Publicerad i European Child & Adolescent Psychiatry
Volym 15
Nummer/häfte 3
Sidor 177-181
ISSN 1018-8827
Publiceringsår 2006
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Sidor 177-181
Språk en
Länkar dx.doi.org/10.1007/s00787-005-0523-...
Ämnesord Adrenergic Uptake Inhibitors, Therapeutic use, Attention Deficit Disorder with Hyperactivity, diagnosis, epidemiology, ethnology, Europe, epidemiology, Female, Humans, Male, Propylamines, Therapeutic use, Prospective Studies, Severity of Illness Index, Sex Distribution, United States, Epidemiology
Ämneskategorier Psykiatri

Sammanfattning

Few large, prospective clinical studies in Europe have assessed the validity and applicability of research methods used to study ADHD in North America. To assess comparability of study populations, we examined baseline patient characteristics from a group of North American studies against those of a large European/African/Australian study. All studies used identical diagnostic assessments and inclusion criteria, with ADHD diagnosis and the presence of comorbid psychiatric conditions confirmed using the KSADS-PL. Raters were trained and assessed to ensure uniform diagnostic and symptom severity rating standards. Six hundred and four patients (mean age = 10.2 years) enrolled in the non-North American study, and 665 patients (mean age = 10.4 years) enrolled in the North American study. The proportion of girls was higher in the North American studies (29.2% vs. 10.4%, p < 0.001). In both groups, most patients had a positive family history of ADHD and previous stimulant treatment. Fewer had the inattentive subtype of ADHD, and mean severity was slightly higher in the non-North American study. Results demonstrate that, when a uniform set of rigorous, standardized diagnostic criteria are used by skilled clinicians, the patient populations identified are generally similar. This supports the practice of generalizing results from treatment studies across geographies.

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