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Strabismus might be a risk factor for amblyopia recurrence.

Artikel i vetenskaplig tidskrift
Författare Josefin Nilsson
Melanie Baumann
Johan Sjöstrand
Publicerad i Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus
Volym 11
Nummer/häfte 3
Sidor 240-2
ISSN 1091-8531
Publiceringsår 2007
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering
Sidor 240-2
Språk en
Länkar dx.doi.org/10.1016/j.jaapos.2007.01...
Ämnesord Amblyopia, etiology, therapy, Atropine, therapeutic use, Child, Child, Preschool, Humans, Mydriatics, therapeutic use, Prospective Studies, Recurrence, Refraction, Ocular, physiology, Risk Factors, Sensory Deprivation, Strabismus, complications, Visual Acuity, physiology
Ämneskategorier Oftalmologi

Sammanfattning

BACKGROUND: Previous reports have suggested that one-fourth of amblyopic subjects present with recurrence of amblyopia even after successful primary treatment. Risk factors for amblyopia recurrence are insufficiently studied, but therapy weaning has recently been suggested as a method for reducing the risk of recurrence. METHODS: In the second phase of a prospective study examining the results of treatment for amblyopia, all 35 children with successful primary amblyopia treatment were put on maintenance therapy. Maintenance therapy consisted of low-intensity patching, atropine, or blurring filter, and all children were regularly examined up to at least 8 years of age. Mean age at start of maintenance therapy was 4.3 years (range, 2-7 years). RESULTS: Of the 35 cases with successful primary treatment, 6 cases deteriorated >or=0.2 logMAR, which was considered recurrence of amblyopia. Two of these cases had a second recurrence. Notably, all six subjects presenting with recurrence had microstrabismus. This finding was just outside statistical significance at the 95% confidence level (p = 0.06), but the sample size was small. All but one of the recurrences appeared within 6 months after successful primary treatment. Age at successful primary treatment or initial interocular difference of visual acuity did not affect the risk of recurrence. CONCLUSIONS: Recurrence of amblyopia occurred in 17% of patients despite maintenance therapy and was associated with microstrabismus. The majority of recurrences occurred within the first 6 months after primary treatment.

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