Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

GH secretory pattern in y… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

GH secretory pattern in young adults who discontinued GH treatment for GH deficiency and decreased longitudinal growth in childhood.

Artikel i vetenskaplig tidskrift
Författare Johan Svensson
Gudmundur Johannsson
Ali Iranmanesh
Kerstin Albertsson-Wikland
Johannes D Veldhuis
Bengt-Åke Bengtsson
Publicerad i European journal of endocrinology / European Federation of Endocrine Societies
Volym 155
Nummer/häfte 1
Sidor 91-9
ISSN 0804-4643
Publiceringsår 2006
Publicerad vid Institutionen för medicin, avdelningen för invärtesmedicin
Institutionen för kliniska vetenskaper
Sidor 91-9
Språk en
Länkar dx.doi.org/10.1530/eje.1.02182
Ämnesord Adolescent, Adult, Body Composition, drug effects, Body Height, drug effects, Entropy, Female, Growth, physiology, Growth Hormone, therapeutic use, Hormone Replacement Therapy, Human Growth Hormone, blood, deficiency, Humans, Luminescence, Male
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

OBJECTIVE: Some adolescents who discontinue GH treatment due to GH deficiency (GHD) and short stature in childhood do not have classical GHD at retesting in adult life. It is unknown whether there is a neuroendocrine disturbance in the spontaneous pattern of GH release in these patients. DESIGN/PATIENTS/METHODS: Thirty-seven adolescents, who had received treatment with GH due to impaired longitudinal growth, were included. The adolescents were divided into two groups; one (GHD; n = 19) with classical GHD in adult life and another (GH sufficient (GHS); n = 18) without classical adult GHD. One year after GH discontinuation, 24-h GH profiles were performed with blood sampling every 30 min. Sixteen matched healthy controls were also studied. All blood samples were analysed using an ultrasensitive GH assay and then, approximate entropy (ApEn) and deconvolution analysis were performed. RESULTS: The GHD group had higher mean ApEn level than the healthy controls (P < 0.05). As measured by deconvolution analysis, they had lower basal GH secretion (P < 0.01), increased number of GH peaks (P < 0.001), but lower burst mass (P < 0.001), lower percentage pulsatile GH secretion (P < 0.001) and lower total GH secretion (P < 0.001), compared with control subjects. Adolescents in the GHS group had a pattern of 24-h GH release similar to that in healthy controls. CONCLUSION: Young adults with childhood-onset severe GHD have a high-frequency, low-amplitude GH secretion with decreased orderliness. The adolescents without classical GHD in adult life maintain a pattern of spontaneous GH release that is not statistically different from that in the healthy controls.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?