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Microvascular behavior and effects of sonazoid microbubbles in the cremaster muscle of rats after local administration.

Artikel i vetenskaplig tidskrift
Författare Magnus Braide
Henrik Højgaard Rasmussen
Ann Albrektsson
Ulf Bagge
Publicerad i Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
Volym 25
Nummer/häfte 7
Sidor 883-90
ISSN 0278-4297
Publiceringsår 2006
Publicerad vid Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi
Sidor 883-90
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Animals, Fluorocarbons, pharmacology, Male, Microbubbles, Muscle, Smooth, blood supply, drug effects, Rats, Testis
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

OBJECTIVE: The purpose of this study was to observe Sonazoid perfluorobutane microbubbles (GE Healthcare, Amersham, Buckinghamshire, England) in and their effects on the cremaster capillary microcirculation of rats. METHODS: Sonazoid (0.3 x 10(9) microbubbles in 0.5 mL) was observed by intravital microscopy in the cremaster muscle after retrograde administration into the femoral artery of 6 animals. Microbubble and microvessel diameters and blood flow velocities and the overall mean and SD of the 1-minute volume flow through the microscopic field were calculated from the 2 to 4 capillaries observed in the field of each animal. Fluorescein isothiocyanate-dextran leakage was used to assess extravasation after microbubble passage. RESULTS: seconds, respectively, before they were released and capillary flow normalized. No microbubble size changes, damming, or coalescence of bubbles and no changes in microvessel diameter or microvascular blood flow velocities, volume flow, or perfusion heterogeneity occurred during or after the passage of the Sonazoid suspension or the vehicle. No fluorescein isothiocyanate-dextran leakage was observed. CONCLUSIONS: The passage of Sonazoid bubbles at concentrations higher than those expected after intravenous administration of the Sonazoid did not durably impair microvascular perfusion, structural integrity, or macromolecular retention in the rat cremaster muscle. The duration of discrete capillary obstructions was short and in all cases comparable with that of naturally occurring leukocyte plugging.

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