Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

A controlled study of col… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

A controlled study of colonic immune activity and beta7+ blood T lymphocytes in patients with irritable bowel syndrome.

Artikel i vetenskaplig tidskrift
Författare Lena Öhman
Stefan Isaksson
Anna Lundgren
Magnus Simrén
Henrik Sjövall
Publicerad i Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Volym 3
Nummer/häfte 10
Sidor 980-6
ISSN 1542-3565
Publiceringsår 2005
Publicerad vid Institutionen för medicinsk mikrobiologi och immunologi
Institutionen för invärtesmedicin, Avdelningen för internmedicin
Sidor 980-6
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adult, CD8-Positive T-Lymphocytes, immunology, Colitis, Ulcerative, immunology, Enzyme-Linked Immunosorbent Assay, Female, Flow Cytometry, Humans, Immunohistochemistry, Integrin beta Chains, analysis, Interferon Type II, analysis, Intestinal Mucosa, immunology, Irritable Bowel Syndrome, immunology, Male, T-Lymphocytes, immunology
Ämneskategorier Gastroenterologi

Sammanfattning

BACKGROUND & AIMS: The mechanisms behind irritable bowel syndrome (IBS) are incompletely understood. Recently several studies have suggested a low-grade colonic inflammation as initiator of the gut dysfunctions recorded in this patient group. The aim of this study was to characterize the phenotype and homing properties of colonic and peripheral blood lymphocytes in patients with IBS. METHODS: Patients with IBS (n=33), defined by the Rome II criteria, were compared with UC patients (n=23) and control subjects (n=15) without gastrointestinal symptoms. Colonic and peripheral blood lymphocytes were analyzed by flow cytometry. Secretion of IFN-gamma from intestinal biopsies was determined by enzyme-linked immunosorbent assay, and immunohistochemical staining of colonic biopsies was performed. RESULTS: IBS patients displayed an increased frequency of peripheral blood CD4+ and CD8+ T cells expressing the gut homing integrin beta7. Accordingly, IBS and UC patients had an augmented frequency of lamina propria CD8+ T cells in the ascending colon as compared with control subjects. The frequency of intestinal T cells expressing integrin beta7+ was unaltered in IBS and UC patients, although the expression of mucosal addressin cell adhesion molecule-1+ endothelium, the ligand for integrin beta7, was increased in the ascending colon of IBS and UC patients as compared with control subjects. CONCLUSIONS: Patients with IBS exhibit an enhanced immune activity in the gut and an increased frequency of integrin beta7+ T lymphocytes in the peripheral blood. Our data further support the hypothesis of IBS being at least partially an inflammatory disorder.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?