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Prevalence of antibodies against herpes simplex virus types 1 and 2 in children and young people in an urban region in Tanzania.

Artikel i vetenskaplig tidskrift
Författare Mabula Joseph Kasubi
Arvid Nilsen
Howard S Marsden
Tomas Bergström
Nina Langeland
Lars Haarr
Publicerad i Journal of clinical microbiology
Volym 44
Nummer/häfte 8
Sidor 2801-7
ISSN 0095-1137
Publiceringsår 2006
Publicerad vid Institutionen för biomedicin, avdelningen för infektionssjukdomar
Sidor 2801-7
Språk en
Länkar dx.doi.org/10.1128/JCM.00180-06
Ämnesord Adolescent, Adult, Antibodies, Viral, blood, Blotting, Western, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Female, HIV, immunology, Herpes Simplex, epidemiology, virology, Herpesvirus 1, Human, immunology, Herpesvirus 2, Human, immunology, Humans, Infant, Male, Seroepidemiologic Studies, Statistics, Tanzania, epidemiology, Urban Population, statistics & numerical data
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

Herpes simplex virus type 1 (HSV-1) is transmitted by close contact, both sexual and nonsexual, and infections are acquired during childhood and adolescence. Herpes simplex virus type 2 (HSV-2), however, is thought to be transmitted mainly by sexual contact. Most HSV-2 infections are consequently expected to occur after the onset of sexual activity. Recent reports indicate an increasing prevalence of HSV-2 on the African continent, but most studies have been performed on adult cohorts. In the present study, we collected sera from Tanzanian children and young persons from 1 to 20 years old, with at least 100 individuals in each age group. Antibodies against HSV-1 and HSV-2 were detected by an in-house Western blot method which was shown to perform well in comparison with a commercial Western blot assay. Type-specific antibodies were also analyzed by two noncommercial enzyme-linked immunosorbent assay methods based upon the antigenicities of branched synthetic oligopeptides corresponding to epitopes in glycoprotein G of HSV-1 or HSV-2. The prevalence of HSV-1 antibodies increased gradually from 73% for the age group of 1 to 4 years to 92% for the age group of 17 to 20 years. The prevalence of HSV-2 antibodies was unexpectedly high, as 15% of the children were infected by the age of 8 years, with the incidence increasing gradually to 40% in the age group of 17 to 20 years. The reason for this unexpectedly high frequency is not clear but could suggest that nonsexual transmission of HSV-2 is more common than previously thought. There was no statistically significant association between seropositivities for HSV-2 and human immunodeficiency virus.

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