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The taqI DRD2 A1 allele is associated with alcohol-dependence although its effect size is small

Artikel i vetenskaplig tidskrift
Författare Ulf Berggren
Claudia Fahlke
Erik Aronsson
Alina (Aikaterini) Karanti
Matts Eriksson
Kaj Blennow
Dag Thelle
Henrik Zetterberg
Jan Balldin
Publicerad i Alcohol
Volym 41
Nummer/häfte 5
Sidor 479-85
ISSN 0735-0414
Publiceringsår 2006
Publicerad vid Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering
Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Psykologiska institutionen
Sidor 479-85
Språk en
Länkar doi.org/10.1093/alcalc/agl043
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adult, Aged, Alcoholism/*genetics, Alleles, Case-Control Studies, Chi-Square Distribution, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Phenotype, Polymerase Chain Reaction, Polymorphism, Genetic, Receptors, Dopamine D2/*genetics, Sweden, Taq Polymerase/genetics
Ämneskategorier Psykologi, Folkhälsomedicinska forskningsområden, Psykiatri

Sammanfattning

BACKGROUND: Numerous studies of the relationship between the TaqIA DRD2 A1 allele and alcohol-dependence have been performed and many of these have shown an association whereas others have not (Noble, 2003). This has consequently generated some controversy as to whether such an association actually exists (Noble, 2003). In the two recent meta-analyses by Noble (2003) and Young et al. (2004) some very important methodological issues have been discussed, which need to be addressed in forthcoming studies. Thus, the sample size is of great importance. In case-control studies it has been estimated that to detect the role of genes with small effect size of approximately 2, which is in the range of the DRD2 A1 allele-alcoholism relationship, case-control sets of 300-400 subjects are necessary (Noble, 2003). METHODS: In the present study, we have consequently recruited a large number of subjects, 375 alcohol-dependent individuals, who were treated as inpatients for alcohol withdrawal symptoms and out of these 357 could be evaluated. As controls, 578 individuals screened and 254 individuals unscreened for alcohol consumption were used. Thus, the total number of subjects was 1217. RESULTS: In the present study, in which the TaqI A1/A2 DRD2 polymorphism was in Hardy-Weinberg equilibrium in the patient group and the two control groups, we found that the TaqI DRD2 A1/A2 genotype frequency differed significantly between the alcohol-dependent group and both the total and screened control groups. Furthermore, the TaqI DRD2 A1 allele frequency was significantly overrepresented in the alcohol-dependent subjects as compared with both the total and screened control groups. The odds ratio for alcohol-dependency being associated with the A1 allele was 1.34. CONCLUSIONS: Consequently, the findings in this study lend further support to the notion of an association between the DRD2 A1 allele and alcohol-dependence, although the effect size of the DRD2 A1 allele is small.

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