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Interleukin-6 gene polymorphism -174G/C influences plasma lipid levels in women.

Artikel i vetenskaplig tidskrift
Författare Susanne Henningsson
Anna Håkansson
Lars Westberg
Fariba Baghaei
Roland Rosmond
Göran Holm
Agneta Ekman
Hans Nissbrandt
Elias Eriksson
Publicerad i Obesity (Silver Spring, Md.)
Volym 14
Nummer/häfte 11
Sidor 1868-73
ISSN 1930-7381
Publiceringsår 2006
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi
Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor 1868-73
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adult, Body Mass Index, Female, Gene Frequency, Genotype, Humans, Interleukin-6, blood, genetics, Lipid Metabolism, genetics, Lipids, blood, Male, Middle Aged, Polymorphism, Genetic, Sex Factors, Triglycerides, blood, metabolism
Ämneskategorier Fysiologi

Sammanfattning

Elevated levels of the pro-inflammatory cytokine interleukin-6 (IL-6) have been associated with cardiovascular risk factors. The objective of this study was to investigate potential associations between the promoter polymorphism IL-6 -174G/C and the following indices of metabolism: BMI, waist-to-hip ratio, and plasma levels of IL-6, cholesterol, low-density lipoprotein, triglycerides, high-density lipoprotein, leptin, and C-reactive protein in 252 42-year-old women and 245 51-year-old men. Subgroups were also studied 5 years later. The CC genotype of the IL-6 polymorphism was associated with lower levels of cholesterol and low-density lipoprotein (p < 0.001) in women. This finding was replicated in the follow-up, when a significant association between the CC genotype and low triglycerides was also observed. The association between the C allele and lipid pattern found in women was not found in men, where on the contrary, C carriers tended to display elevated triglycerides. IL-6 genotype was not associated with IL-6 plasma levels in either sample. The results suggest different effects of the IL-6 polymorphism on metabolic indices in women and men. None of the associations between IL-6 genotype and lipid pattern seemed to result from an effect of the polymorphism on IL-6 plasma levels.

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