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Antibiotic resistance in Staphylococcus aureus colonising the intestines of Swedish infants.

Artikel i vetenskaplig tidskrift
Författare Erika Lindberg
Ingegerd Adlerberth
Agnes E Wold
Publicerad i Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Volym 10
Nummer/häfte 10
Sidor 890-4
ISSN 1198-743X
Publiceringsår 2004
Publicerad vid Institutionen för laboratoriemedicin, Avdelningen för klinisk bakteriologi
Sidor 890-4
Språk en
Länkar dx.doi.org/10.1111/j.1469-0691.2004...
Ämnesord Anti-Bacterial Agents, pharmacology, Bacterial Proteins, chemistry, genetics, Cohort Studies, DNA, Bacterial, chemistry, genetics, Drug Resistance, Multiple, Bacterial, genetics, Feces, microbiology, Humans, Infant, Infant, Newborn, Intestinal Diseases, microbiology, Microbial Sensitivity Tests, Polymerase Chain Reaction, Staphylococcal Infections, microbiology, Staphylococcus aureus, drug effects, genetics, isolation & purification, metabolism, Sweden
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

Staphylococcus aureus has become a frequent coloniser of the intestinal tract of infants, but the health effects of such colonisation are not clear. In this study, the antibiotic resistance patterns of 116 S. aureus strains from the commensal intestinal microflora were determined. The strains were obtained from 81 Swedish infants who had been followed with regular stool samples and registration of antibiotic usage during their first year of life. The faecal population levels of the individual strains and the duration of their persistence in the microflora had been determined previously. The prevalence of antibiotic resistance among the 116 strains was modest: methicillin, 0%; penicillin G, 78%; erythromycin A, 3%; tetracycline, 2%; clindamycin, 0.9%; and fusidic acid, 0.9%. Colonisation by antibiotic-resistant strains was unrelated to antibiotic consumption by individual infants. Antibiotic-resistant strains were as capable of persisting in the intestinal microflora and reaching high faecal population levels as fully susceptible strains. No strain lost or acquired resistance during the colonisation period. Thus, antibiotic-resistant strains of S. aureus seem to be as fit for competition in the large bowel microflora as susceptible strains, even in the absence of selective pressure from antibiotics. This may aggravate the ecological consequences of antibiotic resistance development.

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