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Reduced phase switch capacity and functional adhesin expression of type 1-fimbriated Escherichia coli from immunoglobulin A-deficient individuals.

Artikel i vetenskaplig tidskrift
Författare Forough Nowrouzian
Vanda Friman
Ingegerd Adlerberth
Agnes E Wold
Publicerad i Infection and immunity
Volym 75
Nummer/häfte 2
Sidor 932-40
ISSN 0019-9567
Publiceringsår 2007
Publicerad vid Institutionen för biomedicin, avdelningen för infektionssjukdomar
Sidor 932-40
Språk en
Länkar dx.doi.org/10.1128/IAI.00736-06
Ämnesord Adhesins, Bacterial, biosynthesis, genetics, Adolescent, Adult, Aged, Bacterial Adhesion, DNA, Bacterial, genetics, Escherichia coli, genetics, isolation & purification, physiology, Female, Fimbriae, Bacterial, genetics, metabolism, HT29 Cells, Humans, IgA Deficiency, microbiology, Male, Mannose, metabolism, Middle Aged, Polymerase Chain Reaction
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

The mannose-specific adhesin of type 1 fimbriae is the most common adhesin in Escherichia coli. One receptor for this adhesin is the carbohydrate chains of secretory immunoglobulin A (S-IgA), and intestinal E. coli from IgA-deficient individuals has a reduced capacity to adhere to mannose-containing receptors. Here, we investigated the expression of the mannose-specific adhesin and its capacity to switch to the fimbriated phenotype in colonic resident and transient E. coli strains isolated from control (n = 16) and IgA-deficient (n = 17) persons. Resident E. coli strains from IgA-deficient individuals displayed weaker mannose-specific adherence to colonic cells than resident strains from control individuals (21 versus 44 bacteria/cell, P = 0.0009) due to three mechanisms: a lower carriage rate of the fimH gene (90% versus 97%, not significant), more frequent failure to switch on the fim genes (30% versus 6%, P = 0.02), and the reduced adhesive potential of fimH(+) isolates capable of phase switch (26 versus 46 bacteria/cell, P = 0.02). On the other hand, resident strains from IgA-deficient individuals displayed stronger mannose-resistant adherence than resident strains from control individuals (P = 0.04) and transient strains from IgA-deficient individuals (P = 0.01). The presence of S-IgA appears to favor the establishment of E. coli clones which readily express mannose-specific adhesins in the bowel microbiota.

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