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Effect of human milk on type 1 and P-fimbrial mRNA expression in intestinal Escherichia coli strains.

Artikel i vetenskaplig tidskrift
Författare Forough Nowrouzian
H-J Monstein
Agnes E Wold
Ingegerd Adlerberth
Publicerad i Letters in applied microbiology
Volym 40
Nummer/häfte 1
Sidor 74-80
ISSN 0266-8254
Publiceringsår 2005
Publicerad vid Institutionen för laboratoriemedicin, Avdelningen för klinisk bakteriologi
Sidor 74-80
Språk en
Länkar dx.doi.org/10.1111/j.1472-765X.2004...
Ämnesord Child, Preschool, DNA-Binding Proteins, metabolism, Escherichia coli, genetics, metabolism, Escherichia coli Proteins, metabolism, Fimbriae, Bacterial, genetics, metabolism, Gene Expression Regulation, Bacterial, Genes, Bacterial, Genes, Switch, Humans, Infant, Infant, Newborn, Integrases, metabolism, Intestines, microbiology, Milk, Human, physiology, RNA, Messenger, metabolism, Reverse Transcriptase Polymerase Chain Reaction
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

AIMS: Escherichia coli from breastfed infants express more type 1 fimbriae and less P fimbriae than E. coli from bottle-fed infants. In this study we investigated the effect of human milk on production of mRNA for fimA (type 1 fimbriae) and papC (P fimbriae) in E. coli. METHODS AND RESULTS: Production of adhesin gene mRNA was estimated using a reverse transcriptase polymerase chain reaction in E. coli strains under different culture conditions. More type 1 fimbrial mRNA was produced after culture in human milk (P=0.001) or Luria broth (P=0.014) than after culture on agar, whereas P-fimbrial mRNA production was similar under all tested growth conditions. When cultured on agar, E. coli strains carrying both the fim and pap operons produced less type 1 and P-fimbrial mRNA than strains that had only the fim or pap operons, respectively (P=0.03 and 0.056). SIGNIFICANCE AND IMPACT OF THE STUDY: Environmental regulation of adhesin expression may be influenced by cross-talk between fimbrial operons.

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