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Reduced enterobacterial and increased staphylococcal colonization of the infantile bowel: an effect of hygienic lifestyle?

Artikel i vetenskaplig tidskrift
Författare Ingegerd Adlerberth
Erika Lindberg
Nils Åberg
Bill Hesselmar
Robert Saalman
Inga-Lisa Strannegård
Agnes E Wold
Publicerad i Pediatric research
Volym 59
Nummer/häfte 1
Sidor 96-101
ISSN 0031-3998
Publiceringsår 2006
Publicerad vid Institutionen för biomedicin, avdelningen för infektionssjukdomar
Institutionen för kliniska vetenskaper
Sidor 96-101
Språk en
Länkar dx.doi.org/10.1203/01.pdr.000019113...
Ämnesord Anti-Bacterial Agents, pharmacology, Bacteria, Anaerobic, isolation & purification, Cesarean Section, Enterobacteriaceae, drug effects, isolation & purification, Female, Humans, Hygiene, Hypersensitivity, microbiology, Infant, Newborn, Intestines, microbiology, Life Style, Male, Natural Childbirth, Pregnancy, Staphylococcus, drug effects, isolation & purification
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

The modern Western lifestyle may have altered the composition of the commensal microflora. Here, we investigated the first year's intestinal colonization pattern in 99 vaginally delivered Swedish infants and 17 delivered by cesarean section. Rectal swabs obtained at 3 d of age were cultured for aerobic bacteria and fecal samples obtained at 1, 2, 4, and 8 wk and at 6 and 12 mo of age were cultivated quantitatively for aerobic and anaerobic bacteria. Vaginally delivered infants more often had Escherichia coli compared with cesarean section-delivered infants, whereas the latter more frequently carried other enterobacteria, such as Klebsiella and Enterobacter. Independent of delivery mode, it took 2 mo until most infants were colonized by enterobacteria, traditionally the first colonizers. In contrast, coagulase-negative staphylococci colonized 99% of the infants from d 3 onwards. The poor adaptation of staphylococci to the gut was shown by declining population sizes after some weeks. Dominating anaerobes were initially bifidobacteria and clostridia, whereas Bacteroides initially colonized only 30% of vaginally delivered infants and increased very slowly in prevalence. Bacteroides colonization was delayed up to 1 y in cesarean section-delivered compared with vaginally delivered infants. Our results show that some "traditional" fecal bacteria are acquired late today especially in cesarean section-delivered infants, probably due to limited environmental circulation. In their absence, skin bacteria like staphylococci have become the first gut colonizers.

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