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Procedure-induced inflammation and endothelial cell activation in an artificially ventilated and circulated porcine double-lung model

Artikel i vetenskaplig tidskrift
Författare Katrin Adrian
Maria Skogby
Vladimir Gatzinsky
Lars-Göran Friberg
Karin Mellgren
Publicerad i Artif Organs
Volym 30
Nummer/häfte 12
Sidor 922-8
ISSN 0160-564X (Print)
Publiceringsår 2006
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för pediatrik
Sidor 922-8
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Animals, Endothelium, Vascular/cytology/metabolism, Enzyme-Linked Immunosorbent Assay, Equipment Design, Extracorporeal Circulation/*adverse effects, Female, Inflammation/prevention & control, Interleukin-10/blood, Interleukin-6/blood, Intubation, Intratracheal, Lung/*physiology, Models, Animal, Pulmonary Gas Exchange, Respiration, Artificial/*methods, Statistics, Nonparametric, Swine
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

Systemic inflammation is induced during extracorporeal circulation, resulting in an increased bleeding tendency and endothelial cell activation. Lungs from seven piglets were perfused by autologous blood in an extracorporeal circuit, where the lungs and the left atrium were attached to polyvinyl chloride (PVC) tubings and the blood circulated by a roller pump. The trachea was intubated and attached to a ventilator. The lungs maintained good gas exchange, despite a slight increase in lactate levels. Plasma tPA increased slightly over time, suggesting endothelial cell activation. Activation of inflammatory systems was reflected in increased levels of plasma interleukin (IL)-6 and IL-10. A model for the study of lung endothelial activation during extracorporeal circulation has been shown to be reproducible. The lung tissue was shown to be capable of gas exchange and activation of endothelial cells and procedure-induced inflammation were noted.

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