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Membrane progesterone receptor gamma: tissue distribution and expression in ciliated cells in the fallopian tube.

Artikel i vetenskaplig tidskrift
Författare Magdalena Nutu
Birgitta Weijdegård
Peter Thomas
Christina Bergh
Ann Thurin-Kjellberg
Yefei Pang
Håkan Billig
D. G. Joakim Larsson
Publicerad i Molecular reproduction and development
Volym 74
Nummer/häfte 7
Sidor 843-50
ISSN 1040-452X
Publiceringsår 2007
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi
Institutionen för kliniska vetenskaper
Sidor 843-50
Språk en
Länkar dx.doi.org/10.1002/mrd.20685
Ämnesord Animals, Cell Line, Cilia, metabolism, Fallopian Tubes, cytology, metabolism, Female, Humans, Liver, cytology, metabolism, Mice, Mice, Inbred C57BL, Progesterone, metabolism, Protein Isoforms, genetics, metabolism, Receptors, Progesterone, genetics, metabolism, Tissue Distribution
Ämneskategorier Fysiologi

Sammanfattning

Non-genomic, rapid actions of steroids have long been known, suggesting the possible presence of non-classical steroid receptors. A membrane receptor for progestins (mPR) was recently described in the spotted seatrout, and transcripts of three related receptors (alpha, beta, and gamma) were subsequently identified in other species including human and mouse. To begin exploring the roles of mPRgamma in mammals, we have generated an antibody against this receptor. The specificity of the antibody was demonstrated by both overexpression and RNA interference experiments. Using the antibody, we show that mPRgamma is expressed in female mouse reproductive tissues such as ovary and fallopian tube, and also in the lung and liver of both sexes. Immunohistochemical studies revealed that mPRgamma is associated with the apical membrane of ciliated cells facing the lumen of the fallopian tube. The presence of mPRgamma in ciliated cells of the fallopian tube was also demonstrated in human samples. Rapid effects of progesterone on ciliary beat frequency in the fallopian tube have recently been reported. Together, this suggests a common role for mPRgamma in the regulation of ciliary activity in the fallopian tube and thus gamete transport in mammals. The presence of mPRgamma in lung and liver of mice suggests that the receptor mediates the actions of progesterone outside the reproductive tract as well.

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