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Lactobacilli in the intestinal microbiota of Swedish infants

Artikel i vetenskaplig tidskrift
Författare Siv Ahrne
Elisabeth Lönnermark
Agnes E Wold
Nils Åberg
Bill Hesselmar
Robert Saalman
Inga-Lisa Strannegård
G. Molin
Ingegerd Adlerberth
Publicerad i Microbes and Infection
Volym 7
Nummer/häfte 11-12
Sidor 1256-62
ISSN 1286-4579 (Print)
Publiceringsår 2005
Publicerad vid Institutionen för laboratoriemedicin, Avdelningen för klinisk bakteriologi
Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik
Sidor 1256-62
Språk en
Länkar dx.doi.org/10.1016/j.micinf.2005.04...
Ämnesord Breast Feeding, Colony Count, Microbial, DNA Fingerprinting, DNA, Bacterial/analysis, Feces/microbiology, Humans, Infant, Infant, Newborn, Intestines/*microbiology, Lactobacillus/*classification/growth & development/*isolation &, purification, Polymerase Chain Reaction, Random Amplified Polymorphic DNA Technique, Sweden, Time Factors, Weaning
Ämneskategorier Medicin och Hälsovetenskap, Mikrobiologi inom det medicinska området, Pediatrik

Sammanfattning

Lactobacillus colonisation was examined in 112 Swedish infants. Faecal samples obtained at 1, 2, 4 and 8 weeks and at 6, 12 and 18 months of age were cultivated quantitatively on Rogosa agar. Lactobacilli were speciated by PCR and typed to the strain level by randomly amplified polymorphic DNA (RAPD). Lactobacilli reached a peak at 6 months when 45% of the infants were colonised. L. rhamnosus and L. gasseri were the most common species in this period. Colonisation by lactobacilli in general (P < 0.01) and L. rhamnosus in particular (P < 0.05) was more common in breast-fed than in weaned infants at 6 months of age. Lactobacillus isolation reached a nadir of 17% by 12 months (P < 0.0001), but increased to 31% by 18 months of age P < 0.05). The food-related species L. paracasei, L. plantarum, L. acidophilus and L. delbrueckii dominated in this second phase. A single strain persisted for at least 3 weeks in 17% of the infants during the first 6 months, most commonly L. rhamnosus. Lactobacillus population counts in colonised infants increased from 10(6.4) cfu/g at 1 week to 10(8.8) cfu/g at 6 months, and then dropped to 10(5.4) cfu/g faeces at 12 months of age. Lactobacillus colonisation was not significantly related to delivery mode, or to presence of siblings or pets in the household. Our results suggest that certain Lactobacillus species, especially L. rhamnosus, thrive in the intestinal flora of breast-fed infants. After weaning they are replaced by other Lactobacillus species of types found in food.

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