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Estren promotes androgen phenotypes in primary lymphoid organs and submandibular glands

Artikel i vetenskaplig tidskrift
Författare Ulrika Islander
Bengt Hasséus
Malin Erlandsson
Caroline Jochems
Sofia Movérare-Skrtic
Marie Lindberg
J. A. Gustafsson
Claes Ohlsson
Hans Carlsten
Publicerad i BMC Immunology
Volym 12
Nummer/häfte 6
Sidor 16
ISSN 1471-2172 (Electronic)
Publiceringsår 2005
Publicerad vid Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning
Institutionen för invärtesmedicin, Avdelningen för internmedicin
Odontologiska institutionen, Avdelningen för endodonti med oral diagnostik
Sidor 16
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Animals, Bone Marrow/*drug effects/metabolism, Cell Count, Dihydrotestosterone/pharmacology, Estradiol/analogs & derivatives/pharmacology, Estrenes/*pharmacology, Estrogen Receptor Modulators/pharmacology, Female, Lymphoid Tissue/*drug effects/metabolism, Lymphopoiesis/*drug effects, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Orchiectomy, Organ Specificity, Ovariectomy, Phenotype, Receptors, Androgen/drug effects/physiology, Receptors, Estrogen/deficiency/drug effects/genetics, Sex Characteristics, Submandibular Gland/*drug effects/metabolism, Thymus Gland/*drug effects/metabolism
Ämneskategorier Immunologi inom det medicinska området, Endokrinologi

Sammanfattning

BACKGROUND: Estrogens and androgens have extensive effects on the immune system, for example they suppress both T and B lymphopoiesis in thymus and bone marrow. Submandibular glands are sexually dimorphic in rodents, resulting in larger granular convoluted tubules in males compared to females. The aim of the present experiments was to investigate the estrogenic and androgenic effects of 4-estren-3alpha,17beta-diol (estren) on thymus, bone marrow and submandibular glands, and compare the effects to those of 17beta-estradiol (E2) and 5alpha-dihydrotestosterone (DHT), respectively. Estrogen receptors (ERs) were blocked by treatment of mice with the ER-antagonist ICI 182,780; also, knock-out mice lacking one or both ERs were used. RESULTS: As expected, the presence of functional ERs was mandatory for all the effects of E2. Similar to DHT-treatment, estren-treatment resulted in decreased thymus weight, as well as decreased frequency of bone marrow B cells. Treatment with estren or DHT also resulted in a shift in submandibular glands towards an androgen phenotype. All the effects of estren and DHT were independent of ERs. CONCLUSION: Our study is the first to show that estren has similar effects as the androgen DHT on lymphopoiesis in thymus and bone marrow, and on submandibular glands, and that these effects are independent of estrogen receptors. This supports the hypothesis of estren being able to signal through the androgen receptor.

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