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The methylenetetrahydrofolate reductase C677T polymorphism is a major determinant of coffee-induced increase of plasma homocysteine: a randomized placebo controlled study.

Artikel i vetenskaplig tidskrift
Författare Elisabeth Strandhagen
Henrik Zetterberg
Nibia Aires
Mona Palmér
Lars Rymo
Kaj Blennow
Sverre Landaas
Dag Thelle
Publicerad i International journal of molecular medicine
Volym 13
Nummer/häfte 6
Sidor 811-5
ISSN 1107-3756
Publiceringsår 2004
Publicerad vid Hjärt-kärlinstitutionen
Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin
Sidor 811-5
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adult, Coffee, Female, Folic Acid, pharmacology, Homocysteine, blood, Humans, Male, Methylenetetrahydrofolate Reductase (NADPH2), genetics, Middle Aged, Mutation, Polymorphism, Genetic, genetics
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

Some methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms are associated with hyperhomocysteinemia. Trials have shown a plasma homocysteine raising effect of coffee. We determined the effect of a daily intake of 600 ml coffee and a supplementation of 200 microg folic acid or placebo on plasma homocysteine (tHcy) with respect to the MTHFR C677T and A1298C polymorphisms. One hundred and twenty healthy, non-smoking men (22%) and women (78%) aged 29-65 years, took part in a controlled, randomized, blinded study with two intervention periods: i) a coffee-free period of three weeks, ii) 600 ml coffee/day and a supplement of 200 microg folic acid/d or placebo for four weeks. The results showed that tHcy at baseline was significantly higher for the 677TT genotype group compared to the 677CC genotype group (p=0.0045) and that this group responded with significantly larger increase in tHcy upon coffee exposure than the 677CC and 677CT genotype groups (p=0.0045 and p=0.0041, respectively). Supplementation with 200 microg folic acid compared to placebo reduced the tHcy increasing effect of coffee in the 677TT genotype group. The A1298C polymorphism did not affect tHcy concentration significantly at any stage in the study. In conclusion, the homocysteine increasing effect of coffee is particularly seen in individuals with the homozygous 677TT genotype. Supplementation with 200 microg folic acid/d decreases this tHcy increment.

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