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Fibrous capsule formation around titanium and copper.

Artikel i vetenskaplig tidskrift
Författare Felicia Suska
Lena Emanuelsson
Anna Johansson
Pentti Tengvall
Peter Thomsen
Publicerad i Journal of Biomedical Materials Research Part A
Volym 85
Nummer/häfte 4
Sidor 888-96
ISSN 1549-3296
Publiceringsår 2008
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap
Institutionen för kliniska vetenskaper
Sidor 888-96
Språk en
Länkar dx.doi.org/10.1002/jbm.a.31575
Ämnesord inflammation, fibrosis, angiogenesis, titanium, copper
Ämneskategorier Biomaterialvetenskap, Klinisk medicin

Sammanfattning

Previous studies suggest that implant material properties influence the quality and quantity of fibrous capsule around the implant. However, the precise relation between material surface chemistry, early inflammatory response, and fibrous subsequent repair outcome is still unknown. Titanium (Ti) and copper (Cu), surfaces with different inflammatory potential, were implanted subcutaneously in rats and retrieved fibrous capsules were analyzed after 28 and 56 days. Histological examinations show pronounced differences in capsule morphology. The fibrous capsule around Ti was thinner than that around Cu, with less number of the inflammatory cells in the layer close to the implant surface, and less and smaller blood vessels. The capsule around Cu was thick, with a large number of the inflammatory cells, particularly macrophages and giant cells, and increased number of blood vessels. Our study suggests that material surface properties, which initiate early, multiple cellular inflammatory events, are also associated with increased fibrosis and angiogenesis during repair phase. (c) 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007.

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