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Low adipocyte IRS-1 protein expression is associated with an increased arterial stiffness in non-diabetic males

Artikel i vetenskaplig tidskrift
Författare Madelene Sandqvist
Gunnar Nyberg
Ann Hammarstedt
Natalia Klintland
Silvia Gogg
Kenneth Caidahl
Bo Ahrén
Ulf Smith
Per-Anders Jansson
Publicerad i Atherosclerosis
Volym 180
Nummer/häfte 1
Sidor 119-25
ISSN 0021-9150 (Print)
Publiceringsår 2005
Publicerad vid Hjärt-kärlinstitutionen
Institutionen för invärtesmedicin, Avdelningen för internmedicin
Sidor 119-25
Språk en
Länkar dx.doi.org/10.1016/j.atherosclerosi...
Ämnesord Adipocytes/*metabolism, Adiponectin, Adult, Arteriosclerosis/*metabolism, Biological Markers/metabolism, Blood Glucose, C-Reactive Protein/metabolism, Diabetes Mellitus, Endothelin-1/blood, Fasting, Female, Glucose Clamp Technique, Humans, Hyperinsulinism/metabolism, Insulin Resistance, Intercellular Signaling Peptides and Proteins/blood, Male, Middle Aged, Phosphoproteins/*metabolism
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

OBJECTIVE: Low adipocyte IRS-1 protein expression is a biomarker for insulin resistance and early atherosclerosis. However, whether IRS-1 protein expression is related to systemic arterial stiffness, is unknown. METHODS AND RESULTS: Ten non-diabetic male subjects with low adipocyte IRS-1 protein expression (LIRS) were matched with 10 non-diabetic males with normal IRS-1 protein expression (NIRS). Augmentation index (AIx) and time for reflection of pulse wave (Tr) were studied with pulse wave analysis, both in the fasting state and during a euglycemic hyperinsulinemic clamp. The LIRS-group showed an increased fasting insulin concentration (fP-insulin 71+/-4 pmol/L versus 58+/-5 pmol/L; p=0.02 (mean+/-S.E.)), whereas glucose disposal rate during the clamp (8.7+/-0.8 mg/kg LBM/min versus 10.3+/-1.3 mg/kg LBM/min; n.s.) did not differ significantly. Blood pressure, lipid parameters, adiponectin, endothelin-1 and CRP concentrations were similar. However, in the basal state, AIx was increased (129+/-4% versus 116+/-2%; p<0.02) and Tr was decreased (150+/-3 ms versus 171+/-5 ms; p<0.01), suggesting stiffer vessels in the LIRS-group. The LIRS-group exhibited an attenuated AIx response to hyperinsulinemia compared to the NIRS-group. CONCLUSIONS: The data suggest that non-obese non-diabetic men with a low adipocyte IRS-1 protein expression have an increased systemic arterial stiffness.

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