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Inflammatory response to titanium surfaces with with Potential Bioactive Properties: An In Vitro Study

Artikel i vetenskaplig tidskrift
Författare Anna Göransson
Christina Gretzer
Anna Johansson
Young-Taeg Sul
Ann Wennerberg
Publicerad i Clinical Implant Dentistry and Related Research
Volym 8
Nummer/häfte 4
Sidor 210-217
Publiceringsår 2006
Publicerad vid Institutionen för odontologi
Institutionen för kliniska vetenskaper
Sidor 210-217
Språk en
Länkar www.blackwell-synergy.com/doi/abs/1...
Ämneskategorier Biomaterial

Sammanfattning

Background: The current hard tissue implants research aims to accelerate bone healing by designing surfaces that are bioactive. However, the role of the inflammatory response to these surfaces is so far incompletely described. Purpose: The aim of the study was to evaluate early inflammatory response in vitro to a potentially bioactive surface—an anodized surface with Mg ions incorporated (anodized/Mg)—and to compare it to a turned, a blasted, and an anodized surface. Materials and Methods: An interferometer was used for topographical characterizations. The disks were incubated with human mononuclear cells. Adherent cells were investigated with respect to number of cells, viability, differentiation, and cytokine production with and without lipopolysaccharide stimulation after 24 and 72 hours. Results: The number of adhered mononuclear cells differed significantly between the different modified surfaces, with the highest number on the anodized surface. However, there were no significant differences in cytokine production and differentiation between the different modified surfaces. The amount of anti-inflammatory mediator interleukin-10 remained over time, while the number of cells and pro-inflammatory cytokine tumor necrosis factor-α decreased. The cells were viable on all surfaces, respectively. Conclusion: The anodized surfaces with and without Mg ions showed an increased cell adherence, however, otherwise an inflammatory response similar to the turned and blasted surfaces. Furthermore, the potentially bioactive anodized/Mg surface showed a similar response to the TiUnite-like anodized surface despite the former having a surface roughness of a smoother character.

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