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Fetal brain injury in experimental intrauterine asphyxia and inflammation in Gottingen minipigs

Artikel i vetenskaplig tidskrift
Författare Kristin Lyng
Berit H. Munkeby
David Scheie
Carina Mallard
Henrik Hagberg
Babill Stray-Pedersen
Ola Didrik Saugstad
J. Frederik Froen
Publicerad i J Perinat Med
Volym 34
Nummer/häfte 3
Sidor 226-34
Publiceringsår 2006
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi
Institutionen för kliniska vetenskaper
Sidor 226-34
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Animals, Asphyxia/*pathology, Brain/*embryology/*pathology, Disease Models, Animal, Endotoxins/toxicity, Female, Fetal Diseases/*pathology, Fetal Weight, Inflammation/metabolism/*pathology, Microglia/pathology, Necrosis, Neurons/pathology, Pregnancy, Swine, Swine, Miniature, Tumor Necrosis Factor-alpha/metabolism
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

OBJECTIVE: To examine fetal brain injury in the Gottingen minipig following intrauterine asphyxia and infection/inflammation induced at 3/4 of gestational length. METHODS: We performed laparotomy after anesthesia in six pregnant sows. We randomized 29 fetuses to one of four groups: pretreatment with saline or endotoxin followed by 30 min of umbilical cord occlusion or no occlusion. After 48 h we performed a re-laparotomy and examined the fetal brains. RESULTS: After total asphyxia, brain stem injury was present in the group pretreated with saline (P < 0.01 vs. controls) and with endotoxin (P < 0.005 vs. controls). Microglia activation was more marked in the brain stem (P < 0.05) and posterior white matter (P < 0.05) in the asphyxia group than in controls. Two of five fetuses in the asphyxia group had white matter injury, while no white matter lesions were found in the asphyxia/inflammation or endotoxin only groups. CONCLUSIONS: In this Gottingen minipig model, a species closer to humans than animals commonly used in experimental studies of perinatal brain injuries, intrauterine asphyxia following pretreatment with saline caused brain stem and white matter injury. This model can be further developed to study the impact of other intrauterine exposures on brain injury.

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