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Irradiation at 634 nm releases nitric oxide from human monocytes

Artikel i vetenskaplig tidskrift
Författare Ann Lindgård
Lillemor Mattsson Hultén
L. Svensson
Bassam Soussi
Publicerad i Lasers Med Sci
Volym 22
Nummer/häfte 1
Sidor 30-6
ISSN 0268-8921 (Print)
Publiceringsår 2007
Publicerad vid Wallenberglaboratoriet
Institutionen för kliniska vetenskaper
Sidor 30-6
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adenosine Triphosphate/biosynthesis, Humans, *Laser Therapy, Low-Level, Monocytes/*metabolism/*radiation effects, Nitric Oxide/*metabolism, Reactive Oxygen Species/metabolism
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

Previous studies have shown that irradiation at 634 nm decreases the release of extracellular reactive oxygen species (ROS) without affecting viability in human monocytes. Here, we examined the effect of irradiation at 634 nm on the release of nitric oxide (NO), activation of inducible nitric oxide synthase (iNOS) and endothelial NOS (eNOS), and release of intracellular ROS. Chemiluminescence assays were used to measure NO release, intracellular ROS, and adenosine triphosphate levels (to assess cell viability). Levels of iNOS and eNOS mRNA were analyzed using PCR. Irradiation resulted in elevated levels of NO but had no effect on iNOS or eNOS. Irradiation also caused a decrease in levels of intracellular ROS and had no effect on cell viability. Our studies indicate that irradiation at 634 nm releases NO, possibly from a preformed store, and reduces the production of intracellular ROS without affecting cell viability. Irradiation at 634 nm may have a wide range of clinical applications, including a reduction in oxidative stress-mediated injury in the vasculature.

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