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Health economic evaluation of therapeutic strategies in patients with idiopathic achalasia: results of a randomized trial comparing pneumatic dilatation with laparoscopic cardiomyotomy

Artikel i vetenskaplig tidskrift
Författare Srdjan Kostic
Erik Johnsson
A. Kjellin
Magnus Ruth
Hans Lönroth
M. Andersson
L. Lundell
Publicerad i Surgical endoscopy
Volym 21
Nummer/häfte 7
Sidor 1184-9
ISSN 1432-2218 (Electronic)
Publiceringsår 2007
Publicerad vid Institutionen för kliniska vetenskaper
Sidor 1184-9
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adult, Aged, Balloon Dilatation/*economics/methods, Cost-Benefit Analysis, Esophageal Achalasia/*economics/surgery/*therapy, Esophagoscopy/*economics/methods, Evaluation Studies, Female, Follow-Up Studies, *Health Care Costs, Humans, Length of Stay, Male, Middle Aged, Probability, Prospective Studies, Risk Assessment, Severity of Illness Index, Statistics, Nonparametric, Sweden, Treatment Outcome
Ämneskategorier Medicin och Hälsovetenskap


BACKGROUND: We have prospectively collected information concerning the costs incurred during the management of patients allocated to either forceful dilatation or to an immediate laparoscopic operation because of newly diagnosed achalasia. METHODS: Fifty-one patients with newly diagnosed achalasia were randomized to either pneumatic dilatation to a diameter of 30-40 mm or to a laparoscopic myotomy to which was added a posterior partial fundoplication. Follow-ups were scheduled at 1, 3, 6, and 12 months after inclusion. At each follow-up visit a study nurse interviewed the patients regarding symptoms and their quality of life (QoL) and a health economic questionnaire was completed. In the latter questionnaire, patients were asked to report the presence and character of contacts with the healthcare system since the last visit. RESULTS: In the dilatation group six patients (23%), including the patient who was operated on because of perforation, were classified as failures during the first 12 months of follow-up compared to one (4%) in the myotomy group (p = 0.047). Five of those classified as failures in the dilatation group subsequently had a surgical myotomy and the sixth patient was treated with repeated dilatations. The patient classified as failure in the myotomy group was treated with endoscopic dilatation. The initial treatment cost and the total costs were significantly higher for laparoscopic myotomy compared to a pneumatic dilatation-based strategy (p = 0.0002 and p = 0.0019, respectively). When the total costs were subdivided into the different resources used, we found that the single largest cost item for pneumatic dilatation was that for hospital stay and that for laparoscopic myotomy was the actual operative treatment (operating room time). The cost-effectiveness analysis, relating to the actual treatment failures, revealed that the cost to avoid one treatment failure (incremental cost-effectiveness ratio) amounted to 9239 euros. CONCLUSION: The current prospective, controlled clinical trial shows that despite a higher level of clinical efficacy of laparoscopic myotomy to prevent treatment failure in newly diagnosed achalasia, the cost effectiveness of pneumatic dilatation is superior, at least when a reasonable time horizon is applied.

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