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Changes in pain behavior and histologic changes caused by application of tumor necrosis factor-alpha to the dorsal root ganglion in rats

Artikel i vetenskaplig tidskrift
Författare Y. Murata
A. Onda
Björn Rydevik
I. Takahashi
K. Takahashi
Kjell Olmarker
Publicerad i Spine
Volym 31
Nummer/häfte 5
Sidor 530-5
ISSN 1528-1159 (Electronic)
Publiceringsår 2006
Publicerad vid Institutionen för kliniska vetenskaper
Sidor 530-5
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Administration, Topical, Animals, Behavior, Animal/*drug effects, Dose-Response Relationship, Drug, Female, Ganglia, Spinal/*drug effects/pathology/physiopathology, Heat, Hyperalgesia/*chemically induced/pathology/physiopathology, Lumbar Vertebrae/surgery, Pain, Pain Threshold/*drug effects/physiology, Physical Stimulation, Rats, Rats, Sprague-Dawley, Recombinant Proteins, Sensory Thresholds/drug effects, Touch/drug effects, Tumor Necrosis Factor-alpha/*pharmacology, Zygapophyseal Joint/surgery
Ämneskategorier Ortopedi

Sammanfattning

STUDY DESIGN: Histologic changes in the dorsal root ganglion (DRG) and the nociceptive stimulation thresholds were studied in rats. OBJECTIVE: To examine the effects of tumor necrosis factor-alpha (TNF) with special reference to pain behavior and histology of the DRG. SUMMARY OF BACKGROUND DATA: Recently, it was reported that local application of nucleus pulposus induces a characteristic tissue reaction at the surface of the DRG. However, to our knowledge, there have been no previous reports about the relationship between the histologic changes and pain behavior caused by cytokines. METHODS: Recombinant TNF was applied to the L4 DRG. Mechanical and thermal nociceptive thresholds were tested. The L4 DRG was sectioned and observed by light microscopy. RESULTS: After the application of 5 ng/microL TNF, significant differences were observed in mechanical and thermal stimulation thresholds. At the site of application of TNF, a characteristic a semilunar-shaped enlargement was observed. The average width of the part was significantly larger in the 5 ng/microL TNF application, as compared to the 0.5-ng/microL TNF application. CONCLUSIONS: The higher concentration of TNF used induced allodynia and hyperalgesia responses. Because the region showing the histologic changes was significantly larger after application of the higher concentration of TNF, the reaction of the DRG may be related to pain.

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