Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Endocrine disruption of p… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Endocrine disruption of parr-smolt transformation and seawater tolerance of Atlantic salmon by 4-nonylphenol and 17 beta-estradiol

Artikel i vetenskaplig tidskrift
Författare S. D. McCormick
M. F. O'Dea
A. M. Moeckel
D. T. Lerner
Björn Thrandur Björnsson
Publicerad i General and Comparative Endocrinology
Volym 142
Nummer/häfte 3
Sidor 280-288
ISSN 0016-6480
Publiceringsår 2005
Publicerad vid Zoologiska institutionen
Sidor 280-288
Språk en
Länkar dx.doi.org/10.1016/j.ygcen.2005.01....
Ämnesord endocrine disrupter, osmoregulation, parr-smolt transformation, insulin-like growth factor i, growth hormone, thyroid hormone, cortisol, gill na,k-atpase, estradiol, nonylphenol, salinity tolerance, growth-factor-i, trout oncorhynchus-mykiss, gonadal-steroid hormones, rainbow-trout, gene-expression, k+-atpase, gairdneri richardson, downstream migration, receptor gene, salar smolts
Ämneskategorier Biologiska vetenskaper

Sammanfattning

Sex steroids are known to interfere with the parr-smolt transformation of anadromous salmonids, and environmental estrogens such as nonylphenol have recently been implicated in reduced returns of Atlantic salmon in the wild. To determine the endocrine pathways by which estrogenic compounds affect smolt development and seawater tolerance, groups of juvenile Atlantic salmon were injected with one of five doses (0.5, 2, 10, 40 or 150 mu g g(-1)) of branched 4-nonylphenol (NP), 2 mu g g(-1) of 17 beta-estradiol (E-2), or vehicle, during the parr-smolt transformation in April, and the treatment was repeated 4, 8, and 11 days after the first injection. Plasma was obtained for biochemical analysis 7 and 14 days after initiation of treatment. After 14 days of treatment, additional fish from each treatment group were exposed to seawater for 24 h to assess salinity tolerance. The E, treatment and the highest NP dose resulted in lower salinity tolerance and decreased plasma insulin-like growth factor I (IGF-I) levels, along with elevated levels of plasma vitellogenin and total calcium. Plasma growth hormone levels were elevated at intermediate NP doses only, and not affected by E-2. After 7 days, plasma thyroxine (T-4) levels decreased in a strong, dose-dependent manner in response to nonylphenol, but after 14 days, this suppressive effect of T-4 occurred at the highest NP dose only. Similarly, E-2 decreased plasma T-4 levels at 7, but not 14 days. Plasma 3,3',5-triodo-L-thyronine was reduced by E-2 and the highest NP dose after 7 and 14 days of treatment. Plasma cortisol levels were not affected by any of the treatments. The results indicate that the parr-smolt transformation and salinity tolerance can be compromised by exposure to estrogenic compounds. Suppression of plasma IGF-I levels is a likely endocrine pathway for the effects of estrogenic compounds on hypo-osmoregulatory capacity, and the detrimental effects of E2 and NP on thyroid hormone levels are also likely to compromise the normal parr-smolt transformation of Atlantic salmon. Published by Elsevier Inc.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?