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Peripherally administered growth hormone increases brain dopaminergic activity and swimming in rainbow trout

Artikel i vetenskaplig tidskrift
Författare Viktoria Johansson
S. Winberg
Elisabeth Jönsson
David Hall
Björn Thrandur Björnsson
Publicerad i Hormones and Behavior
Volym 46
Nummer/häfte 4
Sidor 436-443
ISSN 0018-506X
Publiceringsår 2004
Publicerad vid Zoologiska institutionen
Sidor 436-443
Språk en
Länkar dx.doi.org/10.1016/j.yhbeh.2004.03....
Ämnesord growth hormone, dopamine, dopac, homovanillic acid, behavior, locomotor activity, teleost fish, monoamines, salmon oncorhynchus-kisutch, central-nervous-system, recombinant human gh, locomotor-activity, coho salmon, binding-sites, teleost fish, chicken hypothalamus, molecular-cloning, social-dominance
Ämneskategorier Biologiska vetenskaper

Sammanfattning

There is increasing evidence that growth hormone (GH) has important behavioral effects in fish, but the underlying mechanisms are not well understood. To investigate if peripherally administered GH influences the monoaminergic activity of the brain, and how this is correlated to behavior, juvenile rainbow trout were implanted intraperitoneally with ovine GH. Fish were either kept isolated or in groups of five. The physical activity and food intake of the isolated fish were observed after 1 and 7 days, when brains were also sampled. The content of serotonin, dopamine, and noradrenaline and their metabolites in hypothalamus, telencephalon, optic tectum, and brain stem was then analyzed. For fish kept isolated for 7 days following implant, GH increased swimming activity and the levels of the dopamine metabolite 3, 4-hydroxy-phenylacetic acid (DOPAC) were higher in all brain parts examined. In the optic tectum, the levels of the dopamine metabolite homovanillic acid (HVA) were lowered by the GH treatment. One-day GH implant did not affect behavior or monoamine levels of isolated fish. In the fish kept in groups, a 7-day GH implant increased the hypothalamic levels of DOPAC, but not in the other brain parts examined, which may indicate an effect on the brain dopaminergic system from social interactions. It can be concluded that peripherally administered GH may function as a neuromodulator, affecting the dopaminergic activity of the rainbow trout brain, and this is associated with increased swimming activity. (C) 2004 Elsevier Inc. All rights reserved.

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