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The immune risk phenotype is associated with Il-6 in the terminal decline stage: Findings from the Swedish NONA immune longitudinal study of very late life functioning

Artikel i vetenskaplig tidskrift
Författare A Wikby
B.O Nilsson
R Forsey
J Thompson
J Strindhall
S Löfgren
J Ernerudh
G Pawelec
G.F Ferguson
Boo Johansson
Publicerad i Mechanisms Ageing and Development
Sidor 695-704
Publiceringsår 2006
Publicerad vid Psykologiska institutionen
Sidor 695-704
Språk en
Ämnesord Immunology, oldest-old, T cells, Il-6, mortality, inflammation
Ämneskategorier Psykologi

Sammanfattning

In the present NONA immune longitudinal study, we further examine the previously identi-fied T cell immune risk phenotype (IRP), relative inflammatory activity, morbidity and 2-year mortality in very old individuals >90 years. T-cell subsets as well as the inflammatory mark-ers IL-6, IL-10, C-reactive protein, transthyretin and albumin were evaluated. IRP and low-grade inflammation predicted 57% of observed deaths and 97% of survival over 2 years, and was not significantly affected by individuals' health status, suggesting that the physiological ageing processes of T-cell immunosenescence and low-grade inflammation are of primary importance in late life survival. IRP non-survivors showed only a minor inflammatory activity at baseline, but had in contrast to survivors developed increased activity at follow-up. The re-sults suggest a sequence of stages for IRP individuals that begin with acquisition of CMV in-fection in earlier life, followed by generation of CD8+CD28- cells to control persistent CMV infection and eventually the development of an IRP. Intriguingly, we also found that rare in-dividuals moved out of the IRP category by a process of immune suppression, including in-creases in IL-6 and IL-10 and decreases in the number of CD3+CD8+CD28- cells. The fur-ther characterisation of these exceptional individuals may allow insight into remedial ap-proaches for those who remain in the IRP category until death

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