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Platelet monoamine oxidase B (MAO-B) activity and its relationship to DL-fenfluramine-induced prolactin response in healthy men

Artikel i vetenskaplig tidskrift
Författare Matts Eriksson
Ulf Berggren
Claudia Fahlke
Jörgen Engel
Jan Balldin
Publicerad i Journal of Neural Transmission
Volym 113
Sidor 33-41
Publiceringsår 2006
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Psykologiska institutionen
Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi
Sidor 33-41
Språk en
Ämnesord Monoamine oxidase, fenfluramine, serotonin, prolactin, cortisol, healthy controls
Ämneskategorier Farmakologi och toxikologi, Psykiatri, Psykologi

Sammanfattning

Several techniques are used to assess central serotonergic neurotransmission in man, e.g. challenge tests (hormonal and physiological responses to serotonin active drugs), platelet MAO-B activity as well as brain imaging techniques. Little is known about how these tests relate to each other. The aim of the present study was therefore to investigate if platelet MAO-B activity could be related to hormonal and temperature responses to the serotonin active drug DL-fenfluramine in healthy men. Twelve male subjects without any history of psychiatric disorders or drug abuse/dependencies were recruited. Prior to the challenge with 60 mg DL-fenfluramine, which was given orally, blood for determination of platelet MAO-B activity was drawn. Blood samples for determination of serum prolactin and serum cortisol were drawn at baseline and thereafter every hour for the following six hours. In addition, body temperature was measured at the same time-points. ∆-values were calculated as the difference between the baseline values and the highest (prolactin and cortisol) or lowest value (temperature) thereafter. There was a strong positive correlation (r = 0.75, p < 0.02) between platelet MAO-B activity and ∆-prolactin. No correlations were found to ∆-cortisol, ∆-temperature or any of the baseline values. The results support the notion that the peripheral marker platelet MAO-B activity is related to the function of the central serotonergic neurotransmitter system as assessed by the prolactin response to 60 mg DL-fenfluramin.

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