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Complexity of work and risk of Alzheimer's disease: a population-based study of Swedish twins.

Artikel i vetenskaplig tidskrift
Författare Boo Johansson
R Andel
M Crowe
N.L Pedersen
J Mortimer
E Crimmins
M Gatz
Publicerad i J Gerontology: Psychological Science
Sidor 251-8
Publiceringsår 2005
Publicerad vid Psykologiska institutionen
Sidor 251-8
Språk en
Ämnesord Work, Alzheimer’s, twins, elderly
Ämneskategorier Psykologi

Sammanfattning

We examined the association between risk of dementia or Alzheimer's disease (AD) and occupation by using measures of complexity of work with data, people, and things. The study included 10,079 members of the population-based Swedish Twin Registry who were participants in the HARMONY study. We diagnosed dementia by means of a two-stage procedure--cognitive impairment screening fol-lowed by full clinical evaluation. We analyzed data with case-control and cotwin control designs. The cotwin control design provides control over genetic and fa-milial factors. In the case-control study, controlling for age, gender, and level of education, we found that more complex work with people was associated with re-duced risk of AD. Greater complexity of work with people and data was protective in twin pairs discordant for AD. Findings suggest that greater complexity of work, and particularly complex work with people, may reduce the risk of AD.

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