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The Association Between General Childhood Psychopathology and Adolescent Suicide Attempt and Self-Harm: A Prospective, Population-Based Twin Study

Artikel i vetenskaplig tidskrift
Författare L. M. O'Reilly
E. Pettersson
P. D. Quinn
E. D. Klonsky
Sebastian Lundström
H. Larsson
P. Lichtenstein
B. M. D'Onofrio
Publicerad i Journal of Abnormal Psychology
Volym 129
Nummer/häfte 4
Sidor 364-375
ISSN 0021-843X
Publiceringsår 2020
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Sidor 364-375
Språk en
Länkar dx.doi.org/10.1037/abn0000512
Ämnesord suicide attempt, self-harm, adolescence, twin design, general, psychopathology factor, comorbidities a-tac, bifactor model, risk-factors, environmental, contributions, telephone interview, autism-tics, behavior, ideation, disorders, variance, Psychology, Psychiatry
Ämneskategorier Neurologi

Sammanfattning

Few quantitative behavior genetic studies have examined why psychopathology is associated with suicide attempt (SA) and self-harm (SH) in adolescence. The present study analyzed data from the Child and Adolescent Twin Study in Sweden to examine the extent to which genetic and environmental factors explain SA/SH and its association with psychopathology in childhood, an often-cited risk factor of subsequent SA/SH. When children were 9 or 12 years old (n = 30,444), parents completed the Autism-Tics, AD/HD and other Comorbidities Inventory (Larson et al., 2010) regarding their children's psychiatric problems as part of an ongoing, longitudinal study. At age 18 years (n = 10,269), adolescents completed self-report questionnaires, including SA/SH assessments. In a bifactor model of childhood psychopathology, a general factor of psychopathology was a statistically significant predictor of adolescvnt SA/SH at a higher magnitude (beta, 0.25, 95% confidence interval [CI; 0.15, 0.34] for suicide attempt), as compared with specific factors of inattention, impulsivity, oppositional behavior, and anxiety/emotion symptoms. Quantitative genetic modeling indicated that the additive genetic influences on the general factor accounted for the association with each outcome (beta, 0.24, 95% CI [0.13, 0.34] for suicide attempt). The results remained virtually identical when we fit a higher order factors model. Two additional outcomes demonstrated comparable results. The results extend current literature by revealing the shared genetic overlap between general psychopathology during childhood and adolescent SA/SH.

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