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Synthesis and assessment of metallic ion migration through a novel calcium carbonate coating for biomedical implants.

Artikel i vetenskaplig tidskrift
Författare Le Thi Bang
Luimar C Filho
Håkan Engqvist
Wei Xia
Cecilia Persson
Publicerad i Journal of biomedical materials research. Part B, Applied biomaterials
Volym 108
Nummer/häfte 2
Sidor 429-438
ISSN 1552-4981
Publiceringsår 2020
Publicerad vid
Sidor 429-438
Språk en
Länkar dx.doi.org/10.1002/jbm.b.34399
Ämnesord calcium carbonate coating, ion release, protective barrier titanium
Ämneskategorier Biomaterialvetenskap


Titanium (Ti) implants are commonly regarded as well accepted by the body. However, metal ion release is still a cause for concern. A small decrease in pH, which can be caused by inflammation, may produce a large increase in the corrosion rate of Ti implants. Coating the alloy with a buffer layer could have a significant protective effect. In this study, a calcium carbonate coating was developed on commercially pure Ti and a Ti-6Al-4V alloy through a hydrothermal treatment of previously NaOH-treated surfaces in calcium-citric acid chelate complexes. The results showed that a superstructured calcite coating layer formed on the Ti substrate after treatment at 170°C for 3 hr. The coating was approx. 1 μm thick and covered the substrate surface uniformly. When prolonging the hydrothermal treatment from 5 hr to 24 hr, the rhombohedral structure of calcite was observed in addition to the superstructure of calcite. Dissolution test results showed no significant differences in solution pH between the coated- and un-coated samples. However, the CaCO3 coating reduced by approx. 2-5 times the Ti and V ion release from the substrate as compared to the uncoated material, at pH 4. CaCO3 and hydroxyapatite (HA) coatings gave nonsignificant effects at neutral pH although the HA coating showed a trend for better results at the longer time points. The reduction in metal ion release from the substrate and the buffering ability of the CaCO3 coating encourage further studies on this coating for clinical applications.

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