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In vivo safety assessment of a bio-inspired bone adhesive.

Artikel i vetenskaplig tidskrift
Författare Gry Hulsart-Billström
Christina Stelzl
Philip Procter
Michael Pujari-Palmer
Gerard Insley
Håkan Engqvist
Sune Larsson
Publicerad i Journal of materials science. Materials in medicine
Volym 31
Nummer/häfte 2
Sidor 24
ISSN 1573-4838
Publiceringsår 2020
Publicerad vid
Sidor 24
Språk en
Länkar dx.doi.org/10.1007/s10856-020-6362-...
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Biomaterialvetenskap

Sammanfattning

A new class of materials, bone adhesives, could revolutionise the treatment of highly fragmented fractures. We present the first biological safety investigation of a bio-inspired bone adhesive. The formulation was based upon a modified calcium phosphate cement that included the amino acid phosphoserine. This material has recently been described as substantially stronger than other bioresorbable calcium phosphate cements. Four adhesive groups with the active substance (phosphoserine) and two control groups without phosphoserine were selected for in vitro and in vivo biocompatibility testing. The test groups were subject for cell viability assay and subcutaneous implantation in rats that was followed by gene expression analysis and histology assessment after 6 and 12 weeks. All adhesive groups supported the same rate of cell proliferation compared to the α-TCP control and had viability between 45-64% when compared to cell control. There was no evidence of an increased immune response or ectopic bone formation in vivo. To conclude, this bio-inspired bone adhesive has been proven to be safe, in the present study, without any harmful effects on the surrounding soft tissue.

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