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Design and baseline data in the BAriatic surgery SUbstitution and Nutrition study (BASUN): a 10-year prospective cohort study

Artikel i vetenskaplig tidskrift
Författare Gudrun Höskuldsdóttir
Karin Mossberg
Ville Wallenius
Angelos Al Nimer
Wiveka Björkvall
Sören Lundberg
C. J. Behre
Malin Werling
Björn Eliasson
Lars Fändriks
Publicerad i BMC Endocrine Disorders
Volym 20
Nummer/häfte 1
Sidor 9
ISSN 1472-6823
Publiceringsår 2020
Publicerad vid Institutionen för medicin
Institutionen för kliniska vetenskaper
Sidor 9
Språk en
Länkar dx.doi.org/10.1186/s12902-020-0503-...
Ämnesord Obesity, Bariatric surgery, Diet, Prospective study, Cohort study, intensive medical therapy, cardiovascular-disease, obese, scale, disorders, mortality, Endocrinology & Metabolism
Ämneskategorier Endokrinologi och diabetes

Sammanfattning

Background There is still a lack of knowledge on long-term effects of surgical and non-surgical weight-lowering treatments. BASUN is a prospective study with 10 years of follow-up that will observe the effects and consequences of surgical and medical treatment of obesity. The aims are to cover areas where data on long-term outcomes are lacking, e.g., nutritional deficiencies, substance abuse, psychiatric health, as well as patient-reported outcomes. Methods BASUN is a cohort study that recruited study persons with obesity (BMI >= 35 kg/m(2)) referred to the Regional Obesity Centre of Region Vastra Gotaland. The interventions were Roux-en-Y gastric bypass (RYGB) or Sleeve gastrectomy (SG), or 12 months of structured, multi-professional medical treatment (MT), including very low energy diet, followed by diet and pharmaceutical treatment. The study is not randomized, but based on patients preferences and multidisciplinary assessments. The study persons are examined at baseline, 2, 5, and 10 years with blood tests, measurements and questionnaires. The recruitment period lasted from May 2015 to November 2017. Results One thousand one hundred twenty-seven patients were included (74% female). Three hundred eighty-two patients were accepted for medical treatment, 589 for surgical treatment (388 RYGB and 201 SG) and 156 patients left the study without treatment, leaving a final study population of 971 patients. There were slight differences between the treatment groups with regards to age and BMI. Pharmaceutical treatments, level of education, smoking and marital status were not significantly different between the groups. Conclusion This study will follow 971 obese subjects in clinical practice treated with the best surgical or medical methods currently available. It has the potential to evaluate outcomes usually not reported in short-term studies, and to assist in identifying factors that are of importance for the choices of treatment. The main limitations are non-randomization and differences in baseline characteristics. The large number of participants and the length of the prospective follow-up are major strengths of the study. BASUN is designed to identify both early and late benefits and adverse events of treatment of obesity.

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