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Is the anatomical distribution of low-grade gliomas linked to regions of gliogenesis?

Artikel i vetenskaplig tidskrift
Författare Anne Jarstein Skjulsvik
Hans Kristian Bø
Asgeir Store Jakola
Erik Magnus Berntsen
Lars Eirik Bø
Ingerid Reinertsen
Kristin Smistad Myrmel
Kristin Sjåvik
Kristin Åberg
Thomas Berg
Hong Yan Dai
Roar Kloster
Sverre Helge Torp
Ole Solheim
Publicerad i Journal of neuro-oncology
ISSN 1573-7373
Publiceringsår 2020
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap
Språk en
Länkar dx.doi.org/10.1007/s11060-020-03409...
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Neurokirurgi, Neurologi, Cancer och onkologi

Sammanfattning

According to the stem cell theory, two neurogenic niches in the adult human brain may harbor cells that initiate the formation of gliomas: The larger subventricular zone (SVZ) and the subgranular zone (SGZ) in the hippocampus. We wanted to explore whether defining molecular markers in low-grade gliomas (LGG; WHO grade II) are related to distance to the neurogenic niches.Patients treated at two Norwegian university hospitals with population-based referral were included. Eligible patients had histopathological verified supratentorial low-grade glioma. IDH mutational status and 1p19q co-deletion status was retrospectively assessed. 159 patients were included, and semi-automatic tumor segmentation was done from pre-treatment T2-weighted (T2W) or Fluid-Attenuated Inversion Recovery (FLAIR) images. 3D maps showing the anatomical distribution of the tumors were then created for each of the three molecular subtypes (IDH mutated/1p19q co-deleted, IDH mutated and IDH wild-type). Both distance from tumor center and tumor border to the neurogenic niches were recorded.In this population-based cohort of previously untreated low-grade gliomas, we found that low-grade gliomas are more often found closer to the SVZ than the SGZ, but IDH wild-type tumors are more often found near SGZ.Our study suggests that the stem cell origin of IDH wild-type and IDH mutated low-grade gliomas may be different.

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