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Sex-Related Differences in Heart Failure With Preserved Ejection Fraction.

Artikel i vetenskaplig tidskrift
Författare Pooja Dewan
Rasmus Rørth
Valeria Raparelli
Ross T Campbell
Li Shen
Pardeep S Jhund
Mark C Petrie
Inder S Anand
Peter E Carson
Akshay S Desai
Christopher B Granger
Lars Køber
Michel Komajda
Robert S McKelvie
Eileen O'Meara
Marc A Pfeffer
Bertram Pitt
Scott D Solomon
Karl Swedberg
Michael R Zile
John J V McMurray
Publicerad i Circulation. Heart failure
Volym 12
Nummer/häfte 12
Sidor e006539
ISSN 1941-3297
Publiceringsår 2019
Publicerad vid Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor e006539
Språk en
Länkar dx.doi.org/10.1161/CIRCHEARTFAILURE...
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Klinisk medicin

Sammanfattning

To describe characteristics and outcomes in women and men with heart failure with preserved ejection fraction.Baseline characteristics (including biomarkers and quality of life) and outcomes (primary outcome: composite of first heart failure hospitalization or cardiovascular death) were compared in 4458 women and 4010 men enrolled in CHARM-Preserved (Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity) (EF≥45%), I-Preserve (Irbesartan in heart failure with Preserved ejection fraction), and TOPCAT-Americas (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist trial).Women were older and more often obese and hypertensive but less likely to have coronary artery disease or atrial fibrillation. Women had more symptoms and signs of congestion and worse quality of life. Despite this, the risk of the primary outcome was lower in women (hazard ratio, 0.80 [95% CI, 0.73-0.88]), as was the risk of cardiovascular death (hazard ratio, 0.70 [95% CI, 0.62-0.80]), but there was no difference in the rate for first hospitalization for heart failure (hazard ratio, 0.92 [95% CI, 0.82-1.02]). The lower risk of cardiovascular death in women, compared with men, was in part explained by a substantially lower risk of sudden death (hazard ratio, 0.53 [0.43-0.65]; P<0.001). E/A ratio was lower in women (1.1 versus 1.2).There are significant differences between women and men with heart failure with preserved ejection fraction. Despite worse symptoms, more congestion, and lower quality of life, women had similar rates of hospitalization and better survival than men. Their risk of sudden death was half that of men.URL: https://www.clinicaltrials.gov. Unique identifier: NCT00853658, NCT01035255.

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