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Microbial invasion of the amniotic cavity is associated with impaired cognitive and motor function at school age in preterm children.

Artikel i vetenskaplig tidskrift
Författare Anna Thorell
Maria Hallingström
Henrik Hagberg
Ing-Marie Fyhr
Panagiotis Tsiartas
Ingrid Olsson
John E Chaplin
Carina Mallard
Bo Jacobsson
Karin Sävman
Publicerad i Pediatric research
ISSN 1530-0447
Publiceringsår 2019
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi
Språk en
Länkar dx.doi.org/10.1038/s41390-019-0666-...
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Obstetrik och gynekologi, Klinisk medicin

Sammanfattning

Chorioamnionitis is an important cause of preterm delivery. Data on neurodevelopmental outcome in exposed infants are inconsistent due to difficulties in diagnosing intrauterine infection/inflammation and lack of detailed long-term follow-up. We investigate cognitive and motor function in preterm infants at early school age and relate the findings to bacteria in amniotic fluid obtained by amniocentesis (microbial invasion of the amniotic cavity (MIAC)) or placenta findings of histological chorioamnionitis (HCA) or fetal inflammatory response syndrome (FIRS).Sixty-six infants with gestational age <34 weeks at birth and without major disabilities were assessed using WISC-III and the Bruininks-Oseretsky Test of Motor Proficiency. Results were corrected for gestational age and sex.Children exposed to MIAC had significantly lower scores for full-scale IQ and verbal IQ compared to the non-MIAC group and the difference in full-scale IQ remained after correction for confounding factors. The MIAC group had also significantly lower motor scores after correction. In contrast, motor function was not affected in infants exposed to HCA or FIRS and differences between groups for cognitive scores were lost after corrections.Exposure to bacteria in amniotic fluid is associated with lower motor and cognitive scores in school age preterm infants without major disabilities.

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