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Sidan uppdaterades: 2012-09-11 15:12
Författare |
Anna Staffas M. van den Brink |
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Publicerad i | Bone Marrow Transplantation |
Volym | 54 |
Sidor | 756-758 |
ISSN | 0268-3369 |
Publiceringsår | 2019 |
Publicerad vid |
Sahlgrenska Cancer Center Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi |
Sidor | 756-758 |
Språk | en |
Länkar |
dx.doi.org/10.1038/s41409-019-0612-... |
Ämnesord | microbiota, granulopoiesis, nod1, Biophysics, Oncology, Hematology, Immunology, Transplantation |
Ämneskategorier | Biofysik, Immunologi inom det medicinska området, Hematologi, Cancer och onkologi |
Recent studies in both mice and humans have demonstrated that the intestinal microbiota can affect hematopoiesis. Here, we performed experiments in preclinical mouse models for syngeneic and allogeneic HCT. To study the metabolic effects of intestinal flora depletion on post-transplant hematopoiesis in humans, we performed HCT experiments using a metabolic chamber and bomb calorimetry of feces. Taken together, we show that the intestinal microbiota supports post-transplant hematopoietic reconstitution in HCT recipients through its role in dietary energy uptake.