Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

C-Peptide Suppression Dur… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

C-Peptide Suppression During Insulin Infusion in the Extremely Preterm Infant Is Associated With Insulin Sensitivity

Artikel i vetenskaplig tidskrift
Författare William Hellström
Ingrid Hansen-Pupp
Gunnel Hellgren
Eva Engström
Lennart Stigson
Karin Sävman
David Ley
Chatarina Löfqvist
Publicerad i Journal of Clinical Endocrinology and Metabolism
Volym 104
Nummer/häfte 9
Sidor 3902-3910
ISSN 0021-972X
Publiceringsår 2019
Publicerad vid Institutionen för neurovetenskap och fysiologi
Institutionen för biomedicin
Institutionen för vårdvetenskap och hälsa
Institutionen för kliniska vetenskaper, Avdelningen för pediatrik
Sidor 3902-3910
Språk en
Länkar doi.org/10.1210/jc.2018-02681
Ämneskategorier Klinisk medicin

Sammanfattning

Context Little is known about the individual response of glucose-regulating factors to administration of exogenous insulin infusion in extremely preterm infants. Objective To evaluate longitudinal serum concentrations of insulin, C-peptide, and plasma glucose levels in a high-frequency sampling regimen in extremely preterm infants treated with insulin because of hyperglycemia. Design Prospective longitudinal cohort study. Setting Two university hospitals in Sweden between December 2015 and September 2016. Patients and Intervention Serum samples were obtained from nine extremely preterm infants, gestational age between 22 (+3) and 26 (+5) weeks (+ days), with hyperglycemia (plasma-glucose >10 mmol/L) at the start of insulin infusion, at 12, 24, and every 24 hours thereafter during ongoing infusion, and 12, 24, and 72 hours after the end of insulin infusion. Main outcome measures Longitudinal serum concentrations of insulin and C-peptide and plasma glucose levels. Results During insulin infusion, the serum C-peptide concentrations decreased compared with at start of infusion (P = 0.036), and then increased after ending the infusion. Individual insulin sensitivity based on the nonfasting plasma glucose/insulin ratio at the start of insulin infusion correlated with the initial decrease in serum ΔC-peptide[after 12h] (P = 0.007) and the degree of lasting decrease in serum ΔC-peptide[after end of infusion] (P = 0.015). Conclusion Exogenous insulin infusion suppressed the C-peptide concentration to individually different degrees. In addition, the effect of insulin infusion on β cells may be linked to individual insulin sensitivity, where a low insulin sensitivity resulted in a more pronounced decrease in C-peptide during insulin infusion.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?