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Low-grade inflammation causes gap junction-coupled cell dysfunction throughout the body, which can lead to the spread of systemic inflammation

Artikel i vetenskaplig tidskrift
Författare Elisabeth Hansson
Eva Skiöldebrand
Publicerad i Scandinavian Journal of Pain
Volym 19
Nummer/häfte 4
Sidor 639–649
ISSN 1877-8860
Publiceringsår 2019
Publicerad vid Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin
Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap
Sidor 639–649
Språk en
Länkar dx.doi.org/10.1515/sjpain-2019-0061
Ämnesord Ca2+ signaling, endotoxins, gap junction-coupled cell networks, low-grade inflammation, systemic inflammation, Toll-like receptors
Ämneskategorier Immunologi inom det medicinska området, Cell- och molekylärbiologi

Sammanfattning

Gap junction-coupled cells form networks in different organs in the body. These networks can be affected by inflammatory stimuli and become dysregulated. Cell signaling is also changed through connexin-linked gap junctions. This alteration affects the surrounding cells and extracellular matrix in organs. These changes can cause the spread of inflammatory substances, thus affecting other network-linked cells in other organs in the body, which can give rise to systemic inflammation, which in turn can lead to pain that can turn into chronic. This is a review based on literature search and our own research data of inflammatory stimuli that can affect different organs and particularly gap-junction-coupled cells throughout the body. A remaining question is which cell type or tissue is first affected by inflammatory stimuli. Can endotoxin exposure through the air, water and body start the process and are mast cells the first target cells that have the capacity to alter the physiological status of gap junction-coupled cells, thereby causing breakdown of different barrier systems? Is it possible to address the right cellular and biochemical parameters and restore inflammatory systems to a normal physiological level by therapeutic strategies? © 2019 Elisabeth Hansson et al., Scandinavian Association for the Study of Pain. Published by Walter de Gruyter GmbH, Berlin/Boston. All rights reserved.

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