Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Sonic Hedgehog Signaling … - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Sonic Hedgehog Signaling Is Required for Cyp26 Expression during Embryonic Development

Artikel i vetenskaplig tidskrift
Författare Maha El Shahawy
Claes-Göran Reibring
Kristina Hallberg
C. L. Neben
P. Marangoni
B. D. Harfe
O. D. Klein
Anders Linde
Amel Gritli Linde
Publicerad i International Journal of Molecular Sciences
Volym 20
Nummer/häfte 9
ISSN 1422-0067
Publiceringsår 2019
Publicerad vid Institutionen för odontologi
Språk en
Länkar dx.doi.org/10.3390/ijms20092275
Ämnesord Cyp26 enzymes, congenital anomalies, CRE, LoxP, hedgehog signaling, mouse models, retinoic acid, retinoic acid synthesis, apical ectodermal ridge, neural crest cells, all-trans, vitamin-a, limb bud, retinaldehyde dehydrogenase, secondary, palate, receptor-gamma, cleft-lip
Ämneskategorier Cell- och molekylärbiologi

Sammanfattning

Deciphering how signaling pathways interact during development is necessary for understanding the etiopathogenesis of congenital malformations and disease. In several embryonic structures, components of the Hedgehog and retinoic acid pathways, two potent players in development and disease are expressed and operate in the same or adjacent tissues and cells. Yet whether and, if so, how these pathways interact during organogenesis is, to a large extent, unclear. Using genetic and experimental approaches in the mouse, we show that during development of ontogenetically different organs, including the tail, genital tubercle, and secondary palate, Sonic hedgehog (SHH) loss-of-function causes anomalies phenocopying those induced by enhanced retinoic acid signaling and that SHH is required to prevent supraphysiological activation of retinoic signaling through maintenance and reinforcement of expression of the Cyp26 genes. Furthermore, in other tissues and organs, disruptions of the Hedgehog or the retinoic acid pathways during development generate similar phenotypes. These findings reveal that rigidly calibrated Hedgehog and retinoic acid activities are required for normal organogenesis and tissue patterning.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?