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Regulation of phagosome functions by post-translational modifications: a new paradigm.

Forskningsöversiktsartikel
Författare Paul Dean
Tiaan Heunis
Anetta Härtlova
Matthias Trost
Publicerad i Current opinion in chemical biology
Volym 48
Sidor 73-80
ISSN 1879-0402
Publiceringsår 2019
Publicerad vid
Sidor 73-80
Språk en
Länkar dx.doi.org/10.1016/j.cbpa.2018.11.0...
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Animals, Humans, Phagosomes, chemistry, metabolism, Phosphorylation, Protein Processing, Post-Translational, Proteins, analysis, metabolism, Proteomics, methods, Signal Transduction, Ubiquitination
Ämneskategorier Medicinsk cellbiologi, Cellbiologi, Immunologi inom det medicinska området

Sammanfattning

Phagosomes are highly dynamic organelles formed by the uptake of particles through phagocytic innate immune cells such as macrophages. Their key roles in microbe elimination and antigen presentation make them essential for innate and adaptive immunity. However, phagosomes are also important for tissue homeostasis as even in healthy individuals billions of dead cells are phagocytosed each day. In this short review, we highlight how the use of latex beads as inert baits for phagocytosis and subsequent analysis by proteomics has changed our understanding of the phagosome. We further discuss recent data on post-translational modifications such as phosphorylation and ubiquitylation that regulate phagosome functions and demonstrate that the phagosome is not only a 'degradative organelle' but also serves as a subcellular signalling platform.

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