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Measles outbreak in Gothenburg urban area, Sweden, 2017 to 2018: low viral load in breakthrough infections

Artikel i vetenskaplig tidskrift
Författare Nicklas Sundell
L. Dotevall
Martina Sansone
Maria Andersson
Magnus Lindh
T. Wahlberg
Tobias Tyrberg
Johan Westin
Jan-Åke Liljeqvist
Tomas Bergström
Marie Studahl
Lars-Magnus Andersson
Publicerad i Eurosurveillance
Volym 24
Nummer/häfte 17
Sidor 2-12
ISSN 1560-7917
Publiceringsår 2019
Publicerad vid Institutionen för biomedicin, avdelningen för infektionssjukdomar
Sidor 2-12
Språk en
Länkar dx.doi.org/10.2807/1560-7917.Es.201...
Ämnesord health-care workers, vaccine failure, elimination, Infectious Diseases
Ämneskategorier Infektionsmedicin

Sammanfattning

In an outbreak of measles in Gothenburg, Sweden, breakthrough infections (i.e. infections in individuals with a history of vaccination) were common. The objective of this study was to compare measles RNA levels between naive (i.e. primary) and breakthrough infections. We also propose a fast provisional classification of breakthrough infections. Medical records were reviewed and real-time PCR-positive samples geno-typed. Cases were classified as naive, break-through or vaccine infections. We compared clinical symptoms and measles RNA cycle threshold (Ct) values between breakthrough and naive infections. Sixteen of 28 confirmed cases of measles in this outbreak were breakthrough infections. A fast provisional classification, based on previous history of measles vaccination and detectable levels of measles IgG in acute serum, correctly identified 14 of the 16 breakthrough infections, confirmed by IgG avidity testing. Measles viral load was significantly lower in nasopharyngeal samples from individuals with breakthrough compared with naive infections (median Ct-values: 32 and 19, respectively, p < 0.0001). No onward transmission from break-through infections was identified. Our results indicate that a high risk of onward transmission is limited to naive infections. We propose a fast provisional classification of breakthrough measles that can guide contact tracing in outbreak settings.

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