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Cardiorespiratory Fitness Modifies Influence of Sleep Problems on Cerebrospinal Fluid Biomarkers in an At-Risk Cohort

Artikel i vetenskaplig tidskrift
Författare L. L. Law
K. E. Sprecher
R. J. Dougherty
D. F. Edwards
R. L. Koscik
C. L. Gallagher
C. M. Carlsson
Henrik Zetterberg
Kaj Blennow
S. Asthana
M. A. Sager
B. P. Hermann
S. C. Johnson
D. B. Cook
B. B. Bendlin
O. C. Okonkwo
Publicerad i Journal of Alzheimers Disease
Volym 69
Nummer/häfte 1
Sidor 111-121
ISSN 1387-2877
Publiceringsår 2019
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Sidor 111-121
Språk en
Länkar dx.doi.org/10.3233/jad-180291
Ämnesord Alzheimer's disease, amyloid-beta protein, biomarkers, cardiorespiratory fitness, cerebrospinal fluid, alzheimers-disease, wisconsin-registry, cognitive decline, physical-activity, older women, poor sleep, exercise, association, quality, midlife
Ämneskategorier Neurovetenskaper

Sammanfattning

Background: Previous studies indicate that cardiorespiratory fitness (CRF) and sleep are each favorably associated with Alzheimer's disease (AD) pathophysiology, including reduced amyloid-beta (A beta) and tau pathology. However, few studies have examined CRF and sleep in the same analysis. Objective: To examine the relationship between sleep and core AD cerebrospinal fluid (CSF) biomarkers among at-risk healthy late-middle-aged adults and determine whether CRF modifies this association. Methods: Seventy-four adults (age = 64.38 +/- 5.48, 68.9% female) from the Wisconsin Registry for Alzheimer's Prevention participated. Sleep was evaluated using the Medical Outcomes Study Sleep Scale, specifically the Sleep Problems Index I (SPI), which incorporates domains of sleep disturbance, somnolence, sleep adequacy, and shortness of breath. Higher scores indicate greater sleep problems. To assess CRF, participants underwent a graded exercise test. CSF was collected via lumbar puncture, from which A beta(42), total-tau (t-tau), and phosphorylated-tau (p-tau) were immunoassayed. Regression analyses examined the association between SPI and CSF biomarkers, and the interaction between SPI and CRF on these same biomarkers, adjusting for relevant covariates. Results: Higher SPI scores were associated with greater p-tau (p = 0.027) and higher t-tau/A beta(42) (p = 0.021) and p-tau/A beta(42) (p = 0.009) ratios. Analyses revealed significant SPI*CRF interactions for t-tau (p = 0.016), p-tau (p = 0.008), and p-tau/A beta(42)(p = 0.041); with a trend for t-tau/A beta(42) (p = 0.061). Specifically, the relationship between poorer sleep and these biomarkers was significant among less fit individuals, but not among those who were more fit. Conclusion: In a late-middle-aged at-risk cohort, CRF attenuated the association between poor sleep and levels of select CSF biomarkers. This suggests fitness may play an important role in preventing AD by protecting against pathology, even in impaired sleep.

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