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Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort.

Artikel i vetenskaplig tidskrift
Författare Min Kim
Stuart Snowden
Tommi Suvitaival
Ashfaq Ali
David J Merkler
Tahmina Ahmad
Sarah Westwood
Alison Baird
Petroula Proitsi
Alejo Nevado-Holgado
Abdul Hye
Isabelle Bos
Stephanie Vos
Rik Vandenberghe
Charlotte Teunissen
Mara Ten Kate
Philip Scheltens
Silvy Gabel
Karen Meersmans
Olivier Blin
Jill Richardson
Ellen De Roeck
Kristel Sleegers
Régis Bordet
Lorena Rami
Petronella Kettunen
Magda Tsolaki
Frans Verhey
Isabel Sala
Alberto Lléo
Gwendoline Peyratout
Mikel Tainta
Peter Johannsen
Yvonne Freund-Levi
Lutz Frölich
Valerija Dobricic
Sebastiaan Engelborghs
Giovanni B Frisoni
José L Molinuevo
Anders Wallin
Julius Popp
Pablo Martinez-Lage
Lars Bertram
Frederik Barkhof
Nicholas Ashton
Kaj Blennow
Henrik Zetterberg
Johannes Streffer
Pieter J Visser
Simon Lovestone
Cristina Legido-Quigley
Publicerad i Alzheimer's & dementia : the journal of the Alzheimer's Association
Volym 15
Nummer/häfte 6
Sidor 817-827
ISSN 1552-5279
Publiceringsår 2019
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Sidor 817-827
Språk en
Länkar dx.doi.org/10.1016/j.jalz.2019.03.0...
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Neurovetenskaper

Sammanfattning

A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers.This study analyzed 593 plasma samples selected from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery study, of individuals who were cognitively healthy (n = 242), had mild cognitive impairment (n = 236), or had AD-type dementia (n = 115). Logistic regressions were carried out between plasma metabolites (n = 883) and CSF markers, magnetic resonance imaging, cognition, and clinical diagnosis.Eight metabolites were associated with amyloid β and one with t-tau in CSF, these were primary fatty acid amides (PFAMs), lipokines, and amino acids. From these, PFAMs, glutamate, and aspartate also associated with hippocampal volume and memory.PFAMs have been found increased and associated with amyloid β burden in CSF and clinical measures.

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