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Hydroxyl radicals generated by hydrogen peroxide photolysis recondition biofilm-contaminated titanium surfaces for subsequent osteoblastic cell proliferation

Artikel i vetenskaplig tidskrift
Författare K. Nakamura
M. Shirato
T. Tenkumo
T. Kanno
Anna Westerlund
Ulf Örtengren
K. Sasaki
Y. Niwano
Publicerad i Scientific Reports
Volym 9
ISSN 2045-2322
Publiceringsår 2019
Publicerad vid Institutionen för odontologi, sektion 3
Språk en
Länkar dx.doi.org/10.1038/s41598-019-41126...
Ämnesord peri-implantitis, periodontal pathogens, european workshop, host, response, survival, diseases, assay, light, cytocompatibility, decontamination, Science & Technology
Ämneskategorier Parodontologi

Sammanfattning

Titanium dental implants have been successfully used for decades; however, some implants are affected by peri-implantitis due to bacterial infection, resulting in loss of supporting bone. This study aimed to evaluate the effect of an antimicrobial chemotherapy employing H2O2 photolysis-developed to treat peri-implantitis-on biofilm-contaminated titanium surfaces in association with osteoblastic cell proliferation on the treated surface. Titanium discs were sandblasted and acid-etched, followed by contamination with a three-species biofilm composed of Porphyromonas gingivalis, Fusobacterium nucleatum, and Streptococcus mitis. This biofilm model was used as a simplified model of clinical peri-implantitis biofilm. The discs were subjected to ultrasound scaling, followed by H2O2 photolysis, wherein 365-nm LED irradiation of the disc immersed in 3% H2O2 was performed for 5 min. We analysed proliferation of mouse osteoblastic cells (MC3T3-E1) cultured on the treated discs. Compared with intact discs, biofilm contamination lowered cell proliferation on the specimen surface, whereas H2O2 photolysis recovered cell proliferation. Thus, H2O2 photolysis can recover the degraded biocompatibility of biofilm-contaminated titanium surfaces and can potentially be utilised for peri-implantitis treatment. However, to verify the findings of this study in relation to clinical settings, assessment using a more clinically relevant multi-species biofilm model is necessary.

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