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Plasma metabolomic patterns in patients with exhaustion disorder

Artikel i vetenskaplig tidskrift
Författare Jenny Hadrévi
Ingibjörg H Jonsdottir
Per-Anders Jansson
Jan W. Eriksson
Anna Sjörs
Publicerad i Stress
Volym 22
Nummer/häfte 1
Sidor 17-26
ISSN 1025-3890
Publiceringsår 2019
Publicerad vid Institutionen för neurovetenskap och fysiologi
Institutionen för kost- och idrottsvetenskap
Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor 17-26
Språk en
Länkar https://doi.org/10.1080/10253890.20...
Ämnesord biomarkers, Clinical burnout, exhaustion disorder, metabolism, metabolomics, stress
Ämneskategorier Klinisk medicin

Sammanfattning

© 2018, © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Exhaustion disorder (ED) is a stress-related disorder that often implies a great burden on the individual patient as well as on society. Previous studies have shown that ED is associated with metabolic deviations, such as lowered fasting glucose. Several mechanisms have been discussed as a plausible explanation of the lack of energy described by these patients. Metabolic processes and reduced ability to mobilize energy have been suggested as important factors. This study investigated metabolomics in 20 patients diagnosed with ED and compared them with 21 healthy controls. Plasma metabolic profiles were examined in both fasting and nonfasting (postprandial) conditions. Blood plasma samples were analyzed for metabolite content using gas chromatography mass spectrometry. A total of 62 different metabolites were simultaneously detected in each of the samples. Multivariate models indicated systematic differences between patients with ED and healthy controls in both their fasting and nonfasting plasma metabolite levels. Lysine and octadecenoic acid were more abundant and glutamine, glycine, serine and gluconic acid were less abundant in the patients across both conditions. In the present study, we comprehensively and simultaneously screen for changes in a large number of metabolites. Our results show a difference in systemic metabolites between patients with exhaustion disorder and healthy controls both in the fasting and in the postprandial states. Here, we present new potential biomarkers mirroring exhaustion disorder metabolism.Lay summary Exhaustion disorder (ED) patients suffer from stress-related symptoms including a reduced energy level. This study investigates the body’s metabolism in patients with ED, both fasting and after a meal. New potential markers that may help future investigations on ED were identified.

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